Wayne starts in Brockton, Massachusetts in present day. The titular character "sets out on a dirt bike with his new crush Del to take back the 1979 Pontiac Trans Am that was stolen from his father before he died." The car is in Ocala, Florida. Wayne and Del - and host of oddball characters - go on a road trip to get it back. "It is Wayne and Del against the world."

Wayne es la historia cruda y a veces sangrienta de WAYNE (Mark Mckenna), un Harry el Sucio de 16 años con un corazón de oro, quien se dirige en motocicleta a Ocala, Florida, con su nueva enamorada DEL (Clara Bravo) para recuperar el Trans Am 1979 que le robaron a su padre antes de morir.