After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After eight people are fatally poisoned at a deli in New York City, special agents Maggie Bell and OA Zidan trace the crime to an unlikely culprit and conduct a sting operation to prevent further attacks.

Special Agent Maggie Bell, Special Agent OA Zidan and the team investigate the murders of 18 young women with help from a survivor associated with the deceased.

Special Agents Maggie Bell and OA Zidan rush to track down an active sniper with an elusive motive as the body count continues to rise.

Special Agents Maggie Bell and OA Zidan investigate the death of a safety inspector and its possible connection to a leak at a nuclear power plant.

After a senator’s daughter is kidnapped and held for ransom, the FBI is called in to assist with finding the child before their time limit expires. However, in order to do so, they must dig into the senator’s past for clues to who did this to his family.

Maggie and OA hunt down a ruthless group of robbers who are posing as police officers to target armored trucks.

Maggie and OA lead the search for an abducted former biological weapons chemist.

After a key witness and a U.S. marshal are ambushed and killed, Maggie and OA must track down a man who leaked the information that led to their murders.

When an illegal arms broker turned informant is assassinated, OA assumes his identity and goes undercover to stop the sale of dangerous weapons, with help from Maggie and their former FBI instructor, Rowan Quinn.

When a judge and her daughter are murdered after she sentenced a man to life in prison, Maggie and OA search for the killer behind a possible retaliation. Dana has a vested interest in this case as she has a history with the victim.

When an alt-right provocateur is murdered after giving a speech at a university in New York City, Maggie and OA investigate the school's more extreme political groups and rely on OA's sister, Amira, a student, for help.

Maggie and OA are on a mission to find a couple who are behind a spree of violent armed robberies that resulted in the death of an off-duty police officer.

After an investigative journalist is murdered, the team uncovers information linking the suspect to past cases. The victim’s death also strikes a chord with Maggie, leaving her desperate for answers in regard to a traumatic event in her personal life.

A serial bomber appears to be targeting Wall Street’s elite. Maggie and OA search for a suspect who seems dead-set on revenge, while Dana deals with Spencer Briggs, a cocky profiler brought in to consult on the case.

When the daughter of a wealthy family is kidnapped in an attempt to gain notorious internet fame, Maggie and OA discover the kidnapper’s plans go far beyond abduction in order to never be forgotten.

Maggie and Dana struggle to find justice for victims murdered by a serial killer who left a ghoulish mark on all of his victims, while the mayor limits the investigation in order to prevent economical loss.

OA and Maggie team up with members of the FBI’s Fugitives Department to track down a person wanted for murder who is also on America’s top 10 most wanted list.

An American diplomat is killed while being used as a pawn in a dangerous drug ring, and the team must work together to bring them down. Also, Jubal and OA try to help friends from their past fight off their inner demons.

When a controversial senior leader from Egypt comes to New York for a heart transplant, OA struggles to balance his personal opinion with his professional duty when he is assigned to the security detail.

After a decorated FBI agent is murdered, the team investigates and uncovers the man led a double life. Also, Maggie struggles with what information she should reveal to the agent’s widow, who is also her personal friend.

A woman with information about the death of Maggie’s husband is abducted, leading OA and the team to uncover a criminal operation larger than anyone imagined. Also, Dana puts her career in jeopardy when she stands by and allows Maggie to work on this case that has such a personal connection to her.

After a bomb detonates at a restaurant in Queens, the case becomes personal for OA, who grew up eating there. But what initially seems like a terrorist attack reveals itself to be more complex, and OA goes undercover to prevent another incident.

After the son of a prominent Mommy blogger is kidnapped, the team must sweep through her two million followers to find the culprit. Kristen continues to adjust to life as a field agent with her new partner.

After a front-running female presidential candidate, Valerie Caldwell, is targeted with a car bomb, OA and Maggie must hurry to track down the bomber before they strike again. The case leads them to wonder whether this person is targeting Caldwell for her political aspirations or something else.

After a shooting at a nightclub, it appears that the FBI may have ignored previous threats from a local white supremacist group. Also, Kristen wrestles with her commitment to the Bureau and her responsibility to her community.

A loving husband and father of two, Jim Russo, is kidnapped after accidentally getting involved in illegal dealings far beyond what he imagined. Also, Jubal must make a difficult decision regarding his family and their future.

After a Wall Street investor is murdered, the team is led to an insider-trading ring that uses unconventional methods to gain information. OA struggles to maintain confidence in his budding relationship with Mona.

When a board member of a soon-to-be-public medical tech company is murdered, the team tries to find out who had the most to gain from his death. OA is conflicted when pressure to help a family member is at odds with his commitment to tell the truth.

A car crash results in the death of a photographer; Maggie sympathizes with his widow when she notices similarities with her own husband's death.

After an altercation with a student, a teacher goes missing, leading the team to investigate everyone who might have had a grudge against him. Also, a key witness in the case steps up to help, and Maggie does whatever she can to ensure their safety.

A former kidnapping victim is linked to a series of murders that includes the daughter of an NYPD detective. Also, Kristen begins to doubt her ability as an agent after a training exercise leaves her shaken.

After a businessman with a history of harassment claims against him is killed, the team suspects the killer may be one of his many accusers.

A bank holdup leads the team to a safe deposit box, the contents of which have the potential to destroy national security; Kristen is eager to get back into field work while other team members still have their concerns.

The son of a retired FBI agent is kidnapped, and the team must investigate if it's an act of revenge; Isobel must make a hard call when information from the past comes to light.

When a U.S. attorney is found dead steps away from the body of a private escort, the team must piece together what connected the two seemingly random victims. Also, Jubal’s connection with one of the victims makes finding the killer much more personal.

After a truck filled with armour-piercing rifles is hijacked, the team works to discover who stole it, and what they have planned for the stolen weapons. A friend from OA's past returns to help with the case, but OA isn't sure he can trust him.

After the police ignore a desperate father's plea for help, he abducts a billionaire's daughter and holds her hostage in a near-impenetrable safe room until his own missing child is returned to him. Also, Jubal puts his hostage negotiation skills to the test.

When the team is called to the scene of a murder, they quickly suspect political motivation, but when another murder occurs, they work to uncover a common thread before more bodies pile up. Also, Maggie contemplates a decision that could affect her entire career.

Jess LaCroix and his team come to help OA find a fugitive LaCroix arrested years ago after a bus with 26 students goes missing and he's the main suspect.

The crossover continues on FBI: Most Wanted S01E09 Reveille (II).

The FBI team investigates a drug deal gone bad after the body of a college student is found. Also, Detective Hailey Upton temporarily joins the team and finds her usual investigative methods clash with the Bureau's more buttoned-up environment.