Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen’s decision. Bloom gives extra space to Leyla, but she’s in for a surprise. Reynolds and Wilder help a young terminal patient realize his dream to star in a Bollywood show. Iggy has a breakthrough with a challenging patient.

Max tests a bold new cost-saving program that could help both New Amsterdam and its neediest patients. Wilder struggles with a patient’s decision to refuse life-saving surgery. Reynolds comes to an important realization about his father’s behaviors. Iggy takes the leap into online dating.

An explosion at a wedding ceremony sends a stream of injured partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries. While helping a young girl out of a catatonic state, Iggy learns the truth about the wedding.

Max endeavors to save a nurse who has become the subject of a dangerous malpractice probe. Reynolds goes the extra mile to help a group of patients who are being poisoned in their own building. Bloom makes a startling admission to her sister.

Max goes on a mission to make New York safer. Iggy helps a family come to terms with their deaf child’s inability to communicate.

The New Amsterdam staff grapple with the aftermath of the recent Supreme Court decision on abortion rights. Wilder counsels a woman whose pregnancy puts her life in danger. At Brantley's urging, Max endeavors to find a healthcare solution for out-of-state patients. Bloom reveals monumental news to Reynolds.

Max discovers a revenue-generating department at the hospital that has serious legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats a truly inspirational patient and makes plans for his father. Wilder's young patient teaches her not to jump to conclusions in diagnosing.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.

Reynolds finds himself caught between a chance for love and an opportunity to spend precious time with his father. Realizing the consequences of her actions, Bloom makes an unexpected move forward with her sister. Max helps an ICU intern struggling with the loss of a patient. Dr. Wilder receives an offer that forces her to choose between her community and her career.

When Helen Sharpe unexpectedly returns to New York, Max escapes to the wilderness on a corporate retreat with Bloom, Dr. Wilder and Iggy. Fun soon turns into catastrophe that threatens a life. Reynolds agrees to perform a risky surgery on a medical school colleague's young son only to be faced with unexpected challenges outside his control.

Max and Wilder face a dilemma over approvals for a revolutionary cancer drug as Max learns a secret about his own bout with cancer. Reynolds goes the extra mile to correct a dire medical situation. Iggy tries desperately to help a woman in need, but finds the system is working against him.

In the series finale, everyone's story reaches a surprising yet inevitable conclusion.