As Niles and Cliff set out to find a missing Dorothy, Larry is tasked with handling Niles’ old research team when the ageless aeronauts return from space.

The newly “undead” members of the Doom Patrol are inspired to work on themselves. Later, the team is rocked by the arrival of a mysterious woman on a time machine – and a former foe.

Madame Rouge enlists the Doom Patrol’s help after learning about her unsettling past. While the rest of the team works to infiltrate the target, Rita stays behind and finds a surprising connection with their mysterious friend.

Larry and Jane seek new purpose in Keeg and Kay’s absence. Vic attempts to reconnect with his old crew. A mysterious invitation to a retrospective comes at the perfect time for a newly ousted Rita.

When the safety of Danny and everyone housed within is compromised, Dorothy is forced to step up with some unexpected help.