The US Coast Guard combats drug trafficking out of Colombia and Peru.

Intel is received about a possible smuggler, but as USCG Boutwell approach to investigate, the suspects hit full throttle. In Panama, a police interrogation leads to a major drug stash in the swamplands.

A drug stash is found in a deep cave system in Panama; Puerto Rican drug abuse increases.

U.S. Border Patrol works to protect Puerto Rico from drug smugglers; volunteers attempt to save the lives of drug addicts.

A rollover accident interrupts a police search in Puerto Rico. But a new hunt begins when officers learn of trafficking in the Mona Passage.

Panamanian border agents combat drug cartels seeking new routes. The U.S. Navy and U.S. Coast Guard meet to transfer thousands of kilos of drugs.

The U.S Border Patrol receive intel about smugglers heading from the Dominican Republic to Puerto Rico. Several units deploy to the western side of the island only to find 11 migrants that have been abandoned on a remote island nearby.

Local authorities in the Dominican Republic team up with U.S. law enforcement to investigate a cartel boss operating on the island.

A Venezuelan cartel boss is tracked down in the Dominican Republic, after which law enforcement prepares to intercept one of his shipments. Elsewhere, a group of recovering addicts travel to the slums to help others struggling with dependency.

Dominican authorities gather enough evidence to apprehend a cartel boss, but his possible getaway jeopardizes the arrest. Also: Volunteer work to save patients from drug addiction continues in Santo Domingo.

Panamanian police get intel on a drug exchange. Units head out to surprise the traffickers, but the mission takes an unexpected turn. In Puerto Rico, U.S. Customs and Border Protection oversee the arrival of a ferry from the Dominican Republic.

In Panama, police arrest two smugglers who claim local gangs stole their drugs, leading to a hunt for the thieves responsible. Also: U.S. Customs and Border Protection search for narcotics aboard a ferry in Puerto Rico.

The U.S. Coast Guard receive intel from headquarters about a large shipment of drugs moving from Colombia to Panama in small boats called pangas. Because canvassing such a vast area will prove a major challenge, Panama's Navy joins the search effort.