기대하던 고교 생활을 앞둔 알렉사. 암 투병은 당분간 비밀로 하고 싶다. 새 마음, 새 기분으로 머리 염색에 도전한 알렉사와 케이티. 그런데 어쩐지 일이 커진다?

첫 등교를 앞둔 알렉사와 케이티에게 필요한 건? 산뜻한 가발! 쇼핑하던 둘은 생각지 못한 복병을 만난다. 요즘 부쩍 딸에게 어색하게 구는 데이브. 왜 이러는 걸까?

학교에 암 환자가 있다는 소문이 퍼지자 긴장하는 알렉사. 그보다 슬픈 일은 좋아하는 농구를 못하게 된 것. 그래서 케이티가 알렉사 대신 농구부 테스트를 치른다.

낮은 성적, 황당한 실수, 다 괜찮다고? 알렉사는 엄마의 마음을 악용해 더 큰 일탈을 벌인다. 잭을 위해 캠핑을 준비한 제니퍼. 그러나 잭의 관심은 다른 데 있다.

가을 연극 오디션에 도전한 케이티. 바라던 역을 따내지만, 주위의 시선에 점점 자신감이 떨어진다. 한편 잭의 보모로 나선 루카스. 믿어도 괜찮을까?

알렉사의 암 투병이 밝혀지고 모두가 그녀를 응원한다. 하지만 천적 그웨니의 동정까진 못 참아! 기다렸던 월드시리즈의 날, 데이브는 불청객의 방문에 평정심을 잃는다.

연극을 앞두고 키스 장면을 걱정하는 케이티. 로리에게 이 고민을 상담하자, 제니퍼는 서운함을 느낀다. 알렉사도 친구를 연극에 빼앗긴 것 같아 만만치 않게 섭섭하다.

병원에 입원한 알렉사. 암 병동 친구들과 알렉사의 절친 모드에, 케이티는 질투가 난다. 한편 알렉사 때문에 상심에 빠진 로리, 어떻게 해야 그녀가 평화를 찾을 수 있을까?

알렉사는 의사의 권고대로 집에서 안정을 취한다. 아이패드만 있으면 학교 갈 방법은 다 있으니까. 한편, 제니퍼는 '직업 소개의 날'에 참여하러 잭의 학교로 향한다.

추수감사절 요리를 직접 하겠다고 나선 알렉사. 큰소리 빵빵 쳤는데, 뭐 하나 제대로 안 되니 어쩐다? 오랜만에 아버지를 만난 케이티. 반갑지만 어색한 이 기분이란!

데이브는 루카스에게 모교를 보여줄 생각에 잔뜩 들뜬다. 가족이 데이브의 대학 탐방에 나서자, 비밀 밤샘 파티를 준비하는 알렉사. 오늘이 마지막인 것처럼, 놀아보자!

댄스파티에 함께 가기로 한 알렉사와 딜런. 루카스는 단짝을 빼앗긴 것만 같다. 한편 재채기를 멈추지 못하는 데이브. 고양이 때문이라는데, 아무도 그의 말을 믿지 않는다.

댄스파티가 코앞으로 다가왔다. 그런데 독감 주의보라니! 암 때문에 농구도, 연극도 단념했는데, 첫 댄스파티까지 포기하라고? 상심한 알렉사 곁엔 케이티가 있다. 나만 믿어!

Sophomore year is off to a good start for the girls until Katie twists her ankle. That gives Alexa something else to focus on while waiting to hear from her doctor.

Katie is thrilled when chosen to study acting in London. But the $2,000 tuition is way out of her financial range. So she takes on a series of odd jobs trying to come up with the money to send her to the UK.

Katie applies for a job at the coffee shop without telling her mom. When Lucas and Gwenny go out on a date, the girls are determined to sabotage it.

Alexa gets the doctor's OK to play basketball but struggles on the court. A heart-to-heart with another young cancer patient reminds her of how far she has come.

When Alexa and Dylan get into a fight right before the big Halloween party, Katie's sure she can fix it. But what if they're not meant to be together?

Alexa claims she's fine -- so the girls take her shopping for a Sweet 16 dress. Back at the house, a stressed-out Lucas goes to Dave for dating advice.

When Katie needs help prepping for a math midterm, Alexa offers to ask Dylan. Meanwhile, Jennifer still doesn't know her daughter has a job.

Alexa's working overtime to keep Christmas on track. But finding her old hospital bag stirs up memories that throw her off her holiday game.

It's New Year's Eve, and a bold new Katie is finally ready to confess her feelings for Ryan. Cue the fireworks -- and a flaming espresso machine!

An expensive mistake means Katie can't afford to go to London. But she's keeping it a secret so she doesn't ruin Alexa's epic birthday party.

A big fight on the first day of school leaves the girls feeling way out of sync. Lucas starts college, and Lori and Dave toast their 20th anniversary.

Alexa's ready to leave cancer behind her, but it's not that simple. Meanwhile, Katie's trying to balance all the things -- and it's super complicated.

Being there for Spencer brings back memories Alexa would rather forget. Katie looks for leadership opportunities, and Jennifer preps for a date.

Katie and Ryan don't feel the same way about each other anymore, but neither has the heart to say it. Alexa's determined to pass her driver's test.

Alexa's excited to see Dylan again but senses Spencer needs her more. Katie organizes a food drive, and Dave goes overboard on holiday decorating.

Katie aims high to win a community theater competition, putting unnecessary pressure on her friends -- and herself. Lucas reexamines his future.

Alexa struggles to keep her "real" life -- and her life with Spencer -- separate. A horrified Katie's convinced that her mom is dating Gwenny's dad.

Alexa takes Katie miniature golfing to get her mind off the SATs. Lori plays matchmaker when Jennifer hires a handsome handyman.

Alexa eases Katie's anxiety with an epic plan to crush senior year. Jennifer starts her new job, and Jack and Lucas help solve each other's problems.

Alexa's full of advice after getting her driver's license — but she doesn't know everything. Meanwhile at Wired, the new hire is Katie's worst nightmare.

After dating Joe for six months, Jennifer's ready for him to meet her family and friends. It's just dinner ... but Katie's got some concerns.

With college applications looming, an aptitude test reveals Katie's true passion. But pursuing it is scary — and Alexa's "dream job" doesn't feel right.

Alexa agrees to speak at Lori's carnival-themed Stand Up to Cancer fundraiser, where Katie's coffee kiosk brews unexpected jealousy.

College acceptance letters are here. But did Alexa and Katie get into the same school? And why are things suddenly so weird between Alexa and Spencer?

Senior prom is on Saturday, and Katie needs a date. (See also: the courage to tell Alexa something important.) Lori and Joe go overboard at game night.

The girls are finally graduating from high school and getting ready to leave home for college. But will they stay together or go their separate ways?