毛小方（林正英 饰）和七姊妹堂堂主钟君（苑琼丹 饰）之间的矛盾由来已久人尽皆知，然而，钟君的弟弟钟邦（王书麒 饰）实则五世奇人，方小毛得知此时后十分想要收他为徒。一次偶然中，方小毛结识了名为杨飞云（徐少强 饰）的男子，两人相见恨晚，相谈甚欢，很快便成为了好友。令方小毛 没有想到的是，杨飞云人面兽心，他设计陷害方小毛，使得方小毛与钟邦反目成仇。就在方小毛最失落的时候，是钟君一直陪伴在他身旁，两人之间的矛盾和误会烟消云散。杨飞云和僵尸王（李道洪 饰）同流合污，企图祸害人间，方小毛决心阻止此事，一场大战即将拉开序幕。

毛小方帶著徒弟阿帆一生隨路以來宏揚道術，為眾人斬妖除魔，沿路遇上一位女神棍鍾君和志同道合的楊飛雲，豈料鍾君的弟弟鍾邦是五世奇人，與千金小姐余碧心相戀，亦是青梅竹馬，在他們的感情道路上挫折甚多，唯一最大的阻礙就是鍾邦要吃下忘情草才會發揮所有潛能對付更強的妖魔，經多番轉折後才拜毛小方為師，卻因此與姐姐反目。

另外，自從楊飛雲與毛小方結交好友之後，由於他心術不正，而且更沉迷於邪術企圖改變命格，發覺他與好友的八字相沖，更因多次礙他於事，便開始與毛小方誓不兩立，不惜用方法扭轉自己命格，向毛小方報復，結果自己走上不歸路，到監牢才發現自己沒有掌紋，他用置之死後而復生的方式令自己成為大魔頭追擊毛小方，最後毛小方與五世奇人鍾邦聯手打敗了他。

張天師十八代傳人毛小方（林正英飾）為了追蹤殭屍王，與徒弟阿帆（容錦昌飾）一路南下到香港，認識了精通術數命理的楊飛雲（徐少強飾）。小方道術高明，因而聲名大噪，卻引來七姊妹堂的神棍堂主鍾君（苑瓊丹飾）妒忌，兩人成為冤家。偏巧鍾君之弟鍾邦（王書麒飾）竟為學道奇才的五世奇人，在小方極力游說下，鍾邦拜他為師。

誰料飛雲實為陰險狡詐之輩，在得知小方為自己命中剋星後，多番設計陷害，後更不惜以置諸死地而後生的方法成為大魔王。為了對付飛雲，鍾邦被迫忘情棄愛，喝下忘情水，變成五世奇人，忘卻幾經波折才能在一起的愛人余碧心（文頌嫻飾），與小方聯手消滅飛雲。

Zhang Tian-shi's 18th generation disciple, Mao Xiao-fang, heads south to Hong Kong to track down the zombie king. Along the way, he meets Yang Fei-yun, a master of numerology and fortune-telling. Mao gains recognition for his exceptional Taoist abilities, which attracts jealousy from the head of the Seven Sisters Hall, Chung Kwan. Chung is bitter enemies with Mao, but her younger brother Chung Pong, a prodigious student, takes Mao as his teacher. Mao is unaware that Yang is a cunning and treacherous scoundrel. Yang tricks him into a trap, and eventually becomes the Great Demon King. Chung Pong sacrifices his relationship with his lover, Yuh Pak-sum, to become a great Taoist and help Mao defeat Yang.

Ma Đạo Tranh Bá, toàn bộ tập trung những cảnh hồi hộp và hài hước, câu chuyện ảo thuật tìm bắt những ma ranh hút máu người, thầy pháp Tiểu Phương cùng các đệ tử đồng tâm tiêu diệt những con ma hung dữ này. Bởi thế những con ma không được bữa ăn no thù hận quyết không tha thầy Tiểu Phương.