America's love affair with prescription painkillers has led to widespread dependency on opiates. But following a crackdown on their over-prescription, where does this leave the two million Americans who have developed a habit for these high-strength painkillers?

With the pills now becoming increasingly expensive and scarce on the black market, vast numbers of Americans have turned to the cheaper and stronger opiate: heroin. The drug now claims more lives in the US than either car accidents or gun crime. And, for the first time in over two decades, life expectancy in the US is declining - largely attributed to the rise in fatal heroin overdoses.

In Huntington, West Virginia, Louis Theroux embeds himself in an Appalachian community that is being devastated and stretched to its limits by widespread heroin use. With one in ten babies in the city born dependent on opiates and a fatal overdose rate 13 times the national average, this is the epicentre of the most deadly drug epidemic in US history.

Louis spends time with the user community caught in the vice-like grip of drug misuse and follows the emergency services struggling to cope with multiple overdoses each day.

Houston, the fourth largest city in the US, is widely considered to be the number one hub for human trafficking in North America. The US Department of Justice estimates that at least one in five of all the country's victims are trafficked through the city, and most of these people will be forced to work in the sex industry.

In Dark States - Trafficking Sex, Louis spends time with American women working in the city's illegal sex industry and explores the often complex dynamic between prostitute and pimp. He discovers a subculture that plays by rules that are morally challenging to most people and seeks to understand what stops these women breaking free. Louis also embeds with law enforcement on undercover operations and meets Vice Division officers tasked with persuading the working women to speak out against their pimps.