Chastain is flooded with concert goers when a stampede at a music festival grounds leaves many in need of doctors. As Conrad and Nic race to help Josh Robinson, a professional adventure guide with a long list of prior injuries, Devon works with a musician who swears he is sober, even though his toxicology report suggests otherwise. Meanwhile, Bell stirs the pot when the hospital's revered orthopedic surgeon, Dr. Kit Voss, demands a better resident, Julian works to get her boss on Bell's good side and Winthrop continues to push Conrad to believe he's a changed man.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

Halloween at Chastain proves to be just as spooky as ever when Conrad is tasked with diagnosing a young woman admitted to the hospital with extreme night terrors. Meanwhile, Devon faces his first Halloween in the ER, Nic panics over her decision to bring her newly sober sister to Mina's epic annual Halloween party and Bell finds an interesting way to make use of his new assistant.

When patients from the hospital's prescription drug trial start suffering life threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation. Meanwhile, Conrad uses work to cope with the news about his father, and he teams up with Mina, Kit and the Raptor to treat a patient who is suffering as a result of Lane's dangerous treatments. Then, Devon grows worried when he doesn't hear from Julian, and Nic sets her sights on a primary physician for their new clinic.

Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

Chastain picks up the pieces after the fall out with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth. As Conrad and Alec team up to help a young gymnast experiencing mysterious symptoms, Nic focuses on her sister, who's back with their estranged father, Kyle, in tow. Meanwhile, Bell rushes to Kit's aid when her ex-husband comes to the ER needing emergency surgery.

When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery - without the help of The Raptor - to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.

Devon grows concerned when a mother's complaints go unaddressed after her delivery, and pushes Bell to take drastic measures. Conrad is faced with breaking the news to Nic regarding Jessie's worsening condition. Meanwhile, The Raptor, Mina and Kit spring into action when a mother and son enter the ER with devastating injuries.

When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient's life. Nic receives devastating news and is left worrying about her sister's health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.

The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion.

Intending to garner publicity for the hospital, Cain tries to recruit Bell and Kit on a dangerous surgery. The Raptor develops an emotional attachment to a patient. Mina's friend arrives with shocking news.

After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented it. Adaku returns to ask Mina a big favor. Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie's death.

On National Nurses' Day, the nurses are severely understaffed and overworked. Cain performs a dangerous surgery on a new patient. Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. The doctors perform a risky brain surgery. Mina discovers that Adaku has a dangerous heart condition.

Devon and Conrad face a moral dilemma over a suicidal patient who is in need of a liver transplant.

Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad. The doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit when he discovers that her son-in-law may be suffering from a serious disease. Devon and Nic make a shocking discovery about a former patient.

Cain recruits Ezra to help keep an emergency situation under wraps. Nic works to come up with a support system for a patient in need of a lung transplant. Kit's son-in-law's condition continues to worsen.

Just when Derek's condition seems to be improving, a severe complication arises, causing Kitt to fear that he may be the latest victim of Cain's cover-up. When Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life. Meanwhile, Conrad fills in Marshall on the emergency situation facing the hospital and Mina and The Raptor work on saving the heart of a salsa dancer.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong. Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain’s doctors to put aside their personal issues to try and save his life. Conrad and Nic team up to help one of the crash victims, whose secretive past makes it difficult to identify a diagnosis. Meanwhile, Bell brings his TV crew to the hospital in hopes of garnering positive attention for Chastain, and Mina opens up to Nic, only to find out that Nic is holding on to a secret of her own.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital and the doctors plan for their next career moves. Meanwhile, on their last day, the whole staff must work together to save Nic's life after she is injured by a deranged patient.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son and Devon sees an opportunity to fix the system.

When Conrad gets a call from his former army commander who is stranded and wounded in the forest, the trip to save him brings lots of old emotions to the surface. Devon and Kit treat a patient who suffers from sickle cell anemia and encourage her to have a hip replacement to help treat her pain. Meanwhile, The Raptor is pulled away in the middle of an intense surgery, Mina is left to put her skills and finish the surgery on her own and Bell works on reconnecting with his stepson after helping him get hired at the hospital.

On Nic's first day back at Chastain, the man who attacked her is admitted to the ER, causing her to confront her trauma head-on. Cain, now in recovery, is self-conscious of his physical state and sets his eye on taking down Mina. The new intern both struggles and shines throughout her first day, causing Devon and Conrad to wonder if something bigger is going on.

A case becomes personal for the staff when Conrad and Bell treat a pregnant woman who is carrying Jake's future adopted child. Upon hearing surprising news from Princess Nadine, Devon contemplates the future of his love life. On the heels of meeting The Raptor's parents, Mina gets a call that causes her to make a bold decision about her future. Meanwhile, Cain grows closer to Rose and Irving and Jessica tie the knot.

Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans. Meanwhile, Cain faces a harsh reality when Kit gives him the opportunity to prove he is ready to return to the OR. Then, Devon presents Rose with a groundbreaking clinical trial that could help her battle with Sickle Cell Anemia.

When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode. Conrad and Nic work on an injured EMT. Devon and Leela become trapped with a man who has severe head trauma.

With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain. Devon stays by Rose's side as she starts her clinical trial and things take a turn for the worse. Meanwhile, Kit is under pressure to bring Chastain out of debt.

On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything. Devon and Leela stumble upon an apartment fire, where they assist in getting victims safely to Chastain and Leela gets a chance to prove her skills to Raptor. Jake and his husband deal with the complications of Sammie's health. Raptor and Rose receive exciting news.

The wait is over as Conrad and Nic welcome the arrival of their baby girl. Raptor's life begins to fall apart and he is forced to turn to Cain for help. Devon and Bell work together on a complicated surgery that may allow them to save multiple lives. Kit tries to deal with the moral repercussions of financially saving Chastain.

An attack by cyber criminals sends the Chastain ER into a tailspin and Kit tries to figure out whether or not to pay the ransom. The Raptor deals with a personal connection to the patients brought into the ER during the attack, leaving them all vulnerable. Meanwhile, Conrad works on balancing life as a new dad and Devon and Leela debate taking the next step in their relationship.

When one of the doctors is found unconscious in an elevator at Chastain, the staff frantically retraces his steps to figure out the cause. Billie is faced with a personal conflict when she comes face-to-face with the secret she has been hiding all these years. Meanwhile, Bell helps Kit make a decision about a new neurosurgeon joining the team at Chastain.

When an accident brings a familiar patient into the Chastain ER, the doctors must face the reality of figuring out how to proceed with the best care, which leads the whole staff questioning every decision. Meanwhile, The Raptor and Leela deal with a patient returning with the long-term effects of COVID.

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell’s mentor.

While looking for a distraction on Halloween, Conrad treats a group of witches who send the ER into chaos. Also, Devon treats a patient who thinks he is being haunted by ghosts. Meanwhile, on the way back from his vacation, Bell picks up a hitchhiker who is not what he seems to be.

Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

A new group of interns, which include Billie’s son, Trevor, start their first day with Devon at Chastain. Kit and Bell try to convince Conrad to come back to Chastain and The Raptor’s mom ends up back in the ER. Meanwhile, Leela and Padma deal with an unexpected visit from their parents.

Kit hires a surgical coach to watch over Bell and Raptor and help them brush up on their skills. Upon receiving attention from multiple women at the hospital, Conrad contemplates jumping back into the dating scene. Meanwhile, Devon works with an elderly couple.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her indecisive patient's life and The Raptor continues to try to figure out a care plan for his mother. Meanwhile, both Devon and Kit are stretched far too thin trying to balance everything on their plates

When the first day of Kit's experimental Flight Go team program sends Conrad out into the field, he builds a new relationship with a fellow doctor along for the ride. Devon works with Trevor for the first time on a patient with a mysterious fever, the cause of which can't be found. Meanwhile, Bell is hiding a secret from the whole staff and they are starting to become suspicious.

A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his ailing mother in his clinical trial, causing Devon to face a major dilemma

When a lost child is brought into the ER with physical signs of abuse, Conrad and Cade try to get to the bottom of what happened to her. While out shopping, Devon and Leela encounter a woman who is having trouble breathing, and when she arrives at the hospital, Devon takes it upon himself to make sure she feels comfortable with the staff. Meanwhile, Bell eyes an open seat on the State Medical Board and Billie decides it's time to confront her past

A tragic accident occurs at Jessica’s sister’s gender reveal party, putting her brother-in-law’s life in jeopardy. Meanwhile, Conrad, Irving & Trevor work on an influencer whose life was put in danger by a risky cosmetic surgery. Then, Bell is cleared for his first surgery back and Billie is forced to face her past head-on.

When things from Billie's past begin to come to light, she is the subject of whispers and stares around the hospital and the team struggles to find the best way to support her. With the nurse shortage in full swing, a simple cleaning job turns into a horrific disaster that calls for all hands on deck. Meanwhile, Trevor discovers a shocking secret and Padma has a proposal for Leela

As his clinical begins, Devon treats his first patient with a revolutionary medical fluid that doesn’t go as planned. Meanwhile, an overdosed John Doe is rushed to Chastain, leading Conrad straight into a much bigger scandal than he expected. Then, a shocking secret regarding Cade’s past is discovered.

An old friend's heart problems reveal a bigger issue; Billie and Trevor have an emotional reunion.

Conrad treats one of Gigi's fellow classmates whose stomachache turns into something much more serious; Devon takes several interns to a senior living facility; Leela uncovers some unsettling news.

When Conrad confronts a pharmacy owner about fraudulent prescriptions being filled under his name, the situation takes a dangerous turn; the ER is sent into chaos when a street racing accident results in multiple severe injuries.

With Raptor on leave to take care of his mother, the hospital scrambles to stay organized without him. Meanwhile, a camping trip leaves a patient with a fatal disease that none of the doctors have seen before. Then, Bell and Kit devise a plan to help their case with the Medical Board.

Conrad and Cade work with a Medicare patient who sheds some light of prescription fraud. Leela works herself to the brink of exhaustion.

When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status. Meanwhile, Devon and Leela try to juggle the new dynamics of their relationship and Cade's father arrives at Chastain.

A young boy comes into the hospital with a rare disease which leaves his bones incredibly fragile; with his clinical trial officially being declared a success, Devon has some huge decisions to make about the future of his career.

Conrad contemplates his future; Devon is presented with an amazing career opportunity out of state; Ian is faced with a devastating diagnosis; Kit and Bell celebrate their engagement; Padma receives some highly anticipated news.

When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle. Meanwhile, Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.

The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.

When a gunshot victim comes into the ER, his injuries prove to be so catastrophic throughout his body that multiple doctors need to jump on the case. Meanwhile, Ian is faced with a mandatory drug test and Padma prepares for her C-section.

Ian is faced with performing a surgery on a Jane Doe NICU patient while he continues to struggle with his personal issues. Meanwhile, Conrad asks Devon to cover his shift so he can spend a day at home with an anxious Gigi.

A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.

On the day of Kit and Bell’s wedding, Bell and Conrad get pulled away to tend to the ill daughter of a major hospital donor. Meanwhile, Billie takes Gigi and Sammie dress shopping.

Devon sees a traveling British couple who are nervous about the cost of American health care.

After a teenage boy is taken into Chastain for falling unconscious from a suspicious pill, Conrad takes action to find the boy's brother before he meets the same fate. Meanwhile, Dr. Bell deals with being served court papers from a former patient.

Devon prepares to perform the first titanium rib cage implant surgery in the country.

Conrad comes face to face with Nic's dad, Kyle, after 5 years of no contact, when he comes into Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient’s family ignores her recommendation. Meanwhile, Cade musters up the courage to confront Ian about his addiction and Leela grows concerned about Padma.

A famous cardiothoracic surgeon – who happens to be Dr. Yamada’s mentor – comes into Chastain after experiencing heart pain. Meanwhile, Kit breaks the news that the ER will no longer be accepting trauma patients due to budget cuts, and Devon and Conrad help treat a confused woman.

The ER quickly fills up after a heavy storm causes a devastating helicopter crash. Conrad, Devon and the rest of the Chastain doctors rush to treat patients including the helicopter pilot, a barista, and Chastain’s least favorite person, Governor Mark Betz.

Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.