Conrad receives the call he's been waiting for when a heart becomes available for a patient who has been on the transplant list for two years. But when a congressman is admitted to the hospital after a heart attack, he is prioritized and derails Conrad's patient's surgery. Meanwhile, Nic grows suspicious of one of the doctors after a file goes missing, Dr. Bell tries to manipulate Mina and Devon is put to the test when a patient's condition requires a split-second decision.

Much to Bell's dismay, Nic and Conrad decide to admit a homeless Jane Doe, whom they suspect was dumped off by another hospital during Chastain's big Charity Ball. Elsewhere in the hospital, Devon and Irving care for a male escort who offers surprisingly good advice, Micah returns for a checkup and falls even harder for Mina, and Devon's parents are in town.

In a final and drastic attempt to save Nic from Lane's acts of sabotage, Conrad must call in a favor from the one person he promised he never would. Meanwhile, Mina's partnership with The Raptor takes on new colors when Micah is rushed back to Chastain with major heart complications and Dr. Bell's alliance with Lane is put to the ultimate test when one of her patients is readmitted.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

Bell grows frustrated when Marshall Winthrop, Conrad's dad and new chairman of the board, requests Conrad's input in his discussions about the hospital's expenses. As Conrad and Nic work to cut costs for their patients in need, Julian Lynn, a sharp and sophisticated medical device rep, meets the staff at Chastain and inserts herself into the ongoing work of the doctors to promote her costly products. Meanwhile, Mina's relationship with Micah struggles in the wake of his healing process, and Devon is tasked with showing the eager new interns around the hospital.

Conrad goes head-to-head with Bell after he recommends one of Julian's risky medical devices to Zoey, who's already lost one son and is back in the hospital with the other. Nic fears that Conrad may be getting overly attached to his patient. Meanwhile, Mina and Austin grow closer while working on a difficult heart transplant, Devon embarks on a very difficult day and Dr. Lane Hunter returns.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

Chastain picks up the pieces after the fall out with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth. As Conrad and Alec team up to help a young gymnast experiencing mysterious symptoms, Nic focuses on her sister, who's back with their estranged father, Kyle, in tow. Meanwhile, Bell rushes to Kit's aid when her ex-husband comes to the ER needing emergency surgery.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.