Nic e Conrad precisam diagnosticar um casal feliz que está internado com sintomas misteriosos; Bell e Marshall se deparam com uma viagem de trabalho; AJ rejeita um pedido de Bell, apesar do aviso de Mina.

O hospital sofre uma grave escassez de sangue e Conrad deve tentar todos os meios para salvar a vida de um paciente.

Um policial aparece no pronto-socorro com um criminoso ferido que ele pegou em flagrante e cabe à equipe do Chastain mantê-lo vivo para salvar uma vida inocente.

While looking for a distraction on Halloween, Conrad treats a group of witches who send the ER into chaos. Also, Devon treats a patient who thinks he is being haunted by ghosts. Meanwhile, on the way back from his vacation, Bell picks up a hitchhiker who is not what he seems to be.

When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status. Meanwhile, Devon and Leela try to juggle the new dynamics of their relationship and Cade's father arrives at Chastain.

The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.

A famous cardiothoracic surgeon – who happens to be Dr. Yamada’s mentor – comes into Chastain after experiencing heart pain. Meanwhile, Kit breaks the news that the ER will no longer be accepting trauma patients due to budget cuts, and Devon and Conrad help treat a confused woman.