Three concurrent surgeries at the hospital push its staff to the limits. Determined to ease the pressure, Nic requests Jude for one of the operations, making Conrad jealous. Meanwhile, Dr. Lane Hunter sets out to discredit Nic's claims, Devon struggles with a patient who has an embarrassing problem and a charitable contributor comes to the hospital wanting to donate a lot of money to Dr. Lane's oncology program.

Conrad and Devon work tirelessly to save the life of Bradley, a fellow doctor who has fallen through the hospital skylight. As the team contemplates how and why he fell through in the first place, Dr. Bell looks back to when he benched Bradley for falling asleep during surgery. Amidst the madness, Mina is tasked with showing Chastain's new star cardiothoracic surgeon, Dr. AJ Austin, around the hospital, but is caught off-guard by his volatile personality. Meanwhile, Nic finds renewed enthusiasm when she uncovers an oncologist who used to work with Lane, but while paying him a visit, she fears that she's being followed.

Devon and Conrad race against the clock to save the life of a woman who is deteriorating fast from undetermined symptoms. When the patient turns out to be a hero who helps previous criminals get their lives back together, the team relies on her family of ex-cons to help diagnose and treat her. Tensions rise as Nic continues her search for evidence to incriminate Lane, but must simultaneously tend to her sister, Jessie, who is rushed into the ER. Meanwhile, York returns to the hospital with his mother, who is in need of a risky procedure, and comes face-to-face with the stone-cold Dr. AJ Austin.