Josh Futturman feels stuck in his dead-end job as a janitor so all he really does is play Biotic Wars, an unbeatable videogame the rest of the world has given up on. But when Josh beats the game, mysterious visitors from the future appear: the world is in danger, and Josh is the only one who can save it.

In 1969, Josh, Tiger, and Wolf launch a mission to infiltrate a fraternity party and prevent Dr. Kronish from contracting herpes—but the destruction they’ve left in their wake quickly catches up with them.

Tiger and Wolf decide it’s time for Dr. Kronish to die. Josh reluctantly agrees to help—but when he realizes he can’t go through with it, he finds himself caught in Tiger and Wolf’s sights instead.

In the wake of the disastrous attempt to assassinate Dr. Kronish, Tiger and Wolf kick Josh off the mission. When they realize their Time Travel Device is compromised, Josh makes a deal: if he can get them more fuel, they’ll let him back on the team.

Tiger, Wolf, and Josh work to unmask the Biotics undercover at the Kronish Labs Christmas party. Meanwhile, Josh grows closer to his coworker Jeri as she helps him avoid the obsessed policeman hot on Josh’s tail.

With just twenty-seven minutes before a bomb explodes in the head of their captured Biotic, Josh, Tiger, and Wolf hold a high-stakes interrogation in Josh's bedroom while Josh’s unwitting parents host a holiday dinner party downstairs.

Josh, Tiger, and Wolf jump into the future to steal the fuel they desperately need to continue their mission. But when they arrive at their destination, they are confronted by an unexpected enemy.

The end of the mission is in sight as Tiger and Wolf prepare for one final jump into the past. But when Josh’s mom is kidnapped, Josh refuses to let Tiger and Wolf leave before they mount a daring rescue to save her.

Convinced he knows how to stop Dr. Kronish once and for all, Josh commandeers the TTD and leads the team on a mission into the past. But when Wolf goes missing, they have to spilt up, forcing Josh to carry out his insane plan alone.

Still in the past, Josh desperately tries to change Dr. Kronish’s future while not messing up his own. Meanwhile, Tiger and Wolf confront each other over Wolf's wavering dedication to the cause.

Josh discovers that his interference in the past has completely transformed his life…for the better. Wolf and Tiger deal with the aftermath of their failed mission to the past.

Out of time and options, the team reconciles that their actions have made everything much, much worse and plan one final mission to put an end to Dr. Kronish and the Cure forever.