Spider-Man is excited to start his second year as a superhero and as a student at Horizon High, but discovers that Doc Ock also claims to want a second chance.

Spider-Man discovers there is a new Doctor Octopus taking up the mantle from Otto Octavius and finds himself drawn into this new mystery, missing the danger right under his nose.

Spider-Man has to infiltrate the viral superstars known as the Wake Riders in order to figure out what the end game is with their stolen Vulture tech. But things take a dangerous turn as Adrian Toomes is tempted back to the dark side.

Spider-Man teams up with Ms. Marvel to investigate an elite boarding school after its students start displaying out-of-control, super-powered behaviors.

Eddie Brock, who has emerged with the vengeance-filled Venom symbiote, sets his sights on destroying Peter Parker and everything that is Spider-Man.

Spider-Man is two steps behind as Venom kidnaps key figures in Peter Parker's life; demanding a face-off against Peter, Venom holds them hostage at Horizon High.

A mystery villain puts a bounty on Spider-Man's head, bringing on attacks from Panda-Mania, Hippo and Overdrive.

Anya must step up and embrace being the Spider-Girl; Spider-Man is lured into Mysterio's funhouse and learns that there is a bounty on his head.

Spider-Man faces off against his most bizarre bad guy yet, Jack O'Lantern; he turns Prowler, a reluctant villain, to the side of heroes when he helps him save his brother.

Spidey tracks the identity of the mysterious boss that put a price on his head and who has been sending villains after him.

Spider-Man and Miles Morales discover Doc Ock, whose mind has been hiding inside the metal body of the Living Brain, has been behind the mysterious bounty for Spider-Man’s head.

Spider-Man must fight his way through the Super-Villain Holding Facility to challenge the Living Brain, the robot body that houses the mind of Doctor Octopus.

The Bloodgem accidentally reawakens Gwen Stacy's dormant spider-powers, turning her into Ghost Spider!

Doc Ock intends to bring New York to its knees, but his new brain still contains memories of Uncle Ben.

Doc Ock must adjust to his new life as a hero and is tested by rising crime boss Sand Girl.

Superior Spider-Man is confronted by the Avengers who suspect that he is not who he claims to be.

When Cloak and Dagger emerge to take revenge against Tiberius Stone and his company, Alchemax, Superior Spider-Man must take them down to protect the school.

Superior Spider-Man must face his most challenging opponent when Venom escapes from stasis and attacks Midtown High seeking revenge on Peter Parker.

A series of attacks captures the Avengers one-by-one. Spider-Man is left to figure out who is behind the kidnappings.

Spider-Man takes his mission to The Cellar, where he believes The Regent is using his powers of Cloak & Dagger as well as other supervillains to hold the Avengers captive.

Spider-Man has to take down the slick new villain, Slyde, who is stealing various chemicals from around the city in an effort to create a deadly virus that could wipe out New York.

Spider-Man must team up with Spider-Girl Ghost Spider, and Doc Ock to track down a new threat — the mysterious Goblin Nation.

As Spider-Man and Harry Osborn seek the Goblin King to determine who is behind the Goblin Mask, Spider-Man becomes concerned Harry is leading him into trap.

Peter Parker struggles with the duality of his social life at school and hiding his secret identity from everyone, including his best friend Harry Osborn

Spider-Man, Miles Morales, Spider-Girl, Ghost Spider, Harry Osborn and Doc Ock must stop the Goblin King in his newly acquired Goblin Mech Suit before he destroys New York City.