Hondos S.W.A.T.-Team bricht nach Mexiko auf, um einen flüchtigen Kriminellen in die USA zu überführen. Doch dann muss Hondo einen Zeugen retten, der mit dem Fall in Verbindung steht.

Hondo und Hicks suchen verzweifelt nach Powell, der in Mexico City spurlos verschwunden ist, zusammen mit einer Vakuumbombe, die Tausende von Menschenleben fordern könnte. Deacons Stolz geht in einem Boxkampf mit Rocker unter.

Das Team tritt in Aktion, als Yakuza-Attentäter in L.A. auftauchen und es auf einige mysteriöse japanische Auswanderer abgesehen haben. Nichelle sieht ihren Job in Gefahr, als ein Kollege sie beschuldigt, Bestechungsgelder anzunehmen.

Street entdeckt, dass ein Biker-Club einen Vorrat an panzerbrechenden Kugeln gestohlen hat und einen tödlichen Raubüberfall plant. Hondo kämpft mit den Veränderungen am Arbeitsplatz. Nichelle gerät mit einem ehemaligen Kollegen aneinander.

Nachdem ein Gefängnistransporter umgekippt ist, jagt Hondo drei flüchtige Frauen - darunter eine Serienmörderin, die kurz vor einem Amoklauf steht. Während Annie zur Arbeit zurückkehrt, kämpft Deacon mit der Vereinbarkeit von Beruf und Familie.

After the shocking shooting of a member of 20-Squad, Hondo and the team launch a citywide manhunt for the robbery crew responsible. Meanwhile, Deacon's plans for his future hit a snag, and Powell and Alfaro clash over a tricky issue.

The SWAT team faces off with a family of doomsday preppers barricaded inside their fortress of a home, and Deacon finds himself at the center of the storm. Also, Tan clashes with a reporter covering the situation and Powell grapples with meeting the child she gave up for adoption 18 years ago.

When a female robbery crew "honeytraps" and kills several rich VIPs, Hondo and 20-Squad are called in to assist FBI Agent Jackie Vasquez in capturing the dangerous fugitives before the death toll rises. Commander Hicks is shocked when his new love, Maggie, abruptly ends their relationship without rhyme or reason. With help from Deacon and Dr. Wendy, Hicks makes an important decision about his romantic future.

As 20-Squad scrambles to track down a cold-blooded sniper terrorizing Los Angeles, Hondo discovers a link to his own South L.A. neighborhood that brings a personal twist to the hunt for the deadly shooter. Meanwhile, Tan finds himself questioning his leadership abilities while Powell and Alfaro compete in a classic game of SWAT tag.

Tan finds himself on a one-man mission to save his new love interest and her journalist co-workers when mercenaries take over a black-tie correspondents' dinner. After the group escapes, it's up to SWAT to track down the well-trained gunmen.

When a crew of violent eco-terrorists abducts the teenage son of an energy company executive, SWAT must untangle the kidnappers' twisted motives before carrying out a high-stakes rescue mission. Meanwhile, Hondo's involvement in a shooting draws outrage from the very community he's dedicated his career to protecting. And, as Deacon is called on to help with the escalating crisis, he's forced to confront nagging doubts about his retirement.

SWAT faces their deadliest adversary yet when a violent cell of extremists looks to extract vengeance by blowing up half of Los Angeles, potentially killing thousands.