A young boy prostitute is butchered on the Williamsburg Bridge, alienist Laszlo Kreizler, newspaper illustrator John Moore, secretary Sara Howard & police commissioner Theodore Roosevelt investigate outside the law to find a serial killer.

Sara finds a clue and Kreizler tries to connect the evidence left behind by the serial killer. Kreizler takes Moore, Sara, Marcus and Lucius to Delmonico's in New York and informs them they're working together to catch the killer.

Innovative evidence leads the team to discover a crucial element in the case is missing. Kreizler and Moore interview a witness to find out what happened to Moore at the Brothel. Sara attempts to live in a world outside the investigation. Kreizler challenges them to look within themselves.

Kreizler and Moore follow a lead. Sara visits a hospital and is forced to confront her past. Cyrus, Kreizler’s carriage driver, recovers from his injuries. Byrnes and Connor plot against the team.