Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital’s surgical unit. Alone in the world and unable to personally connect with those around him, his only advocate, Dr. Aaron Glassman, challenges the skepticism and prejudices of the hospital’s board and staff when he brings him in to join the team. Shaun will need to work harder than he ever has before, as he navigates his new environment and relationships to prove to his colleagues that his extraordinary medical gifts will save lives.

Dr. Shaun Murphy’s attention to detail complicates his first day at St. Bonaventure Hospital. Meanwhile, Dr. Claire Browne learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.

Dr. Neil Melendez and the team have to wade through legal waters when a husband and wife have to make a life-changing decision about their unborn child. Meanwhile, Dr. Shaun Murphy struggles to adjust to his new environment at home and makes a huge step forward with his colleagues.

Dr. Shaun Murphy has been assigned his first surgery by Dr. Audrey Lim. However, Dr. Marcus Andrews questions whether he is really ready. Meanwhile, as Dr. Claire Brown continues to avoid her complicated emotions about her mother, she and Dr. Morgan Reznick have a patient whose diagnosis has them doubting his story.

The city of San Jose is rocked by a massive earthquake that puts the staff of St. Bonaventure Hospital on high alert as they race to assess the damage and account for the safety of their colleagues and friends. Meanwhile, Dr. Neil Melendez and Dr. Aaron Glassman are attending a charity event when their lives are threatened by the earthquake.

Shaun and Lea’s long-awaited wedding reception is interrupted by a violent attack at the hospital and the entire team must mobilize to save the victims. Meanwhile, the trauma of seeing people he cares for in life-threatening situations is affecting Shaun in more ways than one.