A próxima festa de noivado de Shaun e Lea deixa todos em um clima festivo; uma jovem mãe solteira descobre que seu filho pode ter contraído o câncer de uma fonte surpreendente; Mateo descobre se seus problemas anteriores na América serão resolvidos.

Dr. Shaun Murphy e a equipe correm para salvar o bebê de uma mulher grávida e descobrir sua situação atual como um criminoso condenado complica ainda mais do que eles imaginam. Enquanto isso, o hospital passa por algumas mudanças inesperadas para as quais a equipe não está preparada.

Shaun confronta Salen sobre as muitas mudanças que ela implementou desde sua chegada em São Boaventura. Glassman é forçado a aceitar o seu novo papel no hospital.

Dr. Shaun Murphy and the team treat a young girl whose father’s personal research complicates their treatment plans. Meanwhile, Dr. Park, Dr. Reznick and Dr. Lim’s patient refuses a life-saving lung transplant despite having a family donor.

Dr. Park and Dr. Murphy treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. In addition, Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.

Dr. Shaun Murphy e Dr. Alex Park devem lutar com uma decisão de vida ou morte e decidir entre salvar um paciente em vez de outro. Enquanto isso, a Dra. Morgan Reznick vai longe demais em sua tentativa de ganhar o favor de Salen

Depois de visitar um possível local para casamento, Shaun e Lea passam por um terrível acidente de carro e descobrem Alma, uma jovem mãe grávida que foi gravemente ferida e precisa de atenção médica imediata. De volta a São Boaventura, a condição de Alma piora, e Shaun e os drs. Lim e Jordan são forçados a dar à luz prematuramente. Enquanto isso, o Dr. Glassman fica apreensivo quando uma figura de seu passado pede ajuda

Now that Shaun has called off the wedding, he is forced to confront Lea about their relationship and determine what he really means to her. Meanwhile, the team debate their opinions on plastic surgery and Dr. Audrey Lim hopes to expose Salen’s cover-up over an infant’s death to take her down before it is too late.

In an effort to please Salen, Andrews takes on a high-profile case and assigns Shaun and Allen to help perform a risky surgery to restore the voice of a famous pop star.

Salen takes extreme measures when she learns that the surgical staff have joined Lim's efforts against her. The team treats a liver transplant patient whose organ donor unwittingly gave him cancer.

Dr. Shaun Murphy makes a personal connection with a precoious young patient which threatens his objectivity. Meanwhile, while volunteering at a long-term care facility, Dr. Morgan Reznick realizes she could help Dr. Aaron Glassman’s clinic by offering telemedicine services for nursing homes and care facilities.

Drs. Lim, Park and Wolke treat a woman with Valley fever and discover a secret she has been hiding from her fiancé. Meanwhile, Drs. Murphy, Allen and Andrews treat a 45-year-old virgin and help her make a big decision about her life.

While Drs. Lim, Murphy and Wolke help a teenage “biohacker” whose self- experiments begin to compromise his health, Drs. Morgan, Park, Jordan and Glassman treat a young woman who wants a controversial surgery to treat her depression and chronic pain. Additionally, Dr. Reznick looks to take the next step in her relationship with Dr. Park.

When someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck, much of the hospital staff and doctors are incapacitated -- leaving doctors Murphy, Glassman and Allen forced to take on all the hospital's cases, further exacerbating Dr. Murphy and Dr. Glassman's conflicting work styles.

While Doctor Andrews treats a foster kid for injuries sustained at his group home, Shaun and team look to Lea's expertise with cars and auto repair to help a patient whose iron lung has broken. Meanwhile, the patient's niece, a documentarian, takes an interest in Shaun.

As Shaun and Lea head toward their wedding day, a documentary film maker has chosen to follow their lives to showcase relationships and weddings of atypical couples.

Sophie takes Lea out for a day full of luxurious wedding planning. And after a near fatal oversight, Dr. Lim senses an underlying issue is behind nurse Villanueva's unprofessional behavior.

Shaun and Lea make a big life decision and are pleasantly surprised by the support they receive from their friends at the hospital. Meanwhile, when Dr. Wolke's parents show up with a revelation, Asher struggles to accept that he and his father may never truly understand one another.