After Dr. Shaun Murphy treats a patient who is a social influencer, he deals with unwanted attention. Meanwhile, the team treats a woman who is in abdominal distress after an at-home fecal transplant; and Dr. Carly Lever’s efforts to separate Shaun from Lea are challenged.

Despite everyone else’s doubts, Shaun is hopeful that Carly is truly fine with his friendship with Lea. The team treats a young boy born without a fully formed trachea and unable to speak, and who may be a good candidate for an experimental procedure.

When Dr. Shaun Murphy makes an emotional confession, the result may not be as desired. Meanwhile, he becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; and Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a male college student with a mysterious split personality disorder.

The city of San Jose is rocked by a massive earthquake that puts the staff of St. Bonaventure Hospital on high alert as they race to assess the damage and account for the safety of their colleagues and friends. Meanwhile, Dr. Neil Melendez and Dr. Aaron Glassman are attending a charity event when their lives are threatened by the earthquake.

Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Dr. Claire Brown and the team must face hard truths about what lines they are willing to cross when one of Claire's idols becomes her patient.

When someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck, much of the hospital staff and doctors are incapacitated -- leaving doctors Murphy, Glassman and Allen forced to take on all the hospital's cases, further exacerbating Dr. Murphy and Dr. Glassman's conflicting work styles.