En ung kirurg, med autisme tiltræder den kirurgiske enhed på St. Bonaventure hospital. Han skal lære at navigere i det nye miljø og bevise at hans specielle medicinske evner kan redde liv.

Dr. Shaun Murphys fokus på detaljer gør hans første dag på det nye job indviklet. Dr. Claire Browne lærer en værdifuld lektie om at være ærlig, da hun står overfor en svær patientdiagnose.

Dr. Melendez og dr. Unger opdager at en patient ikke er helt ærlig overfor dem. Dr. Browne må lære at tale med dr. Murphy, mens de haster tilbage til hospitalet med et doneret organ.

Lovgivningen sætter begrænsninger, da en mand og hans hustru skal tage en livsændrende beslutning for deres ufødte barn. Dr. Shaun Murphy kæmper for at tilpasse sig de nye omgivelser derhjemme.

Dr. Shaun Murphy møder en ung patient, der har en skræmmende lighed med hans afdøde bror. Shaun opdager at hans forældre skjulte hans diagnoser for ham.

Shaun og Claire må eksperimentere sig frem for at redde en ung brudgom ben og liv. Jared har det svært med en patient, hvis skader kan være for dybe til at kunne heles.

Dr. Shaun Murphy møder fordomme fra en uventet kant, da han behandler en autistisk patient. Dr. Jared Kalu må se sine egne begrænsninger som kirurg i øjnene.

En grønthandel, som Shaun handler hos, bliver udsat for røveri, og hans begrænsede evne til at kommunikere, udsætter andre for livsfare. Aaron er bekymret for om han gør nok, for at hjælpe Shaun.

Holdet tager sig af en lille dreng fra Congo, der har en alvorlig, medfødt hjertefejl. Murphys seneste møde med sin nabo Lea, gør ham forvirret.

En charmerende ung læge får sat en kollega i en akavet situation. Dr. Glassman foreslår at dr. Shaun Murphy skal mødes med en terapeut.

Dr. Marcus Andrews hverver dr. Neil Melendez til at udføre en meget vanskelig nyretransplantation. Dr. Shaun Murphy beslutter at tage på en spontan tur med sin ven Lea, for at glemme sine problemer.

Komplikationer tvinger holdet til at tage en svær beslutning for tvillingernes fremtidige liv. Efter sin udflugt med Lea, beslutter Shaun at han har brug for mere permanente forandringer.

Dr. Shaun Murphy har mistanke om at hans patient lyver om årsagen til hendes tilskadekomst. Dr. Neil Melendez's privatliv påvirker hans arbejde - og dermed også hans patienters liv.

Dr. Shaun Murphy bliver overrasket over at finde ud af, at en ung kræftpatient identificerer sig selv som pige, til trods for at være biologisk mand.

En operation, der kan rette en teenagers hjertefejl, skaber uenighed mellem Shaun og dr. Morgan. En ny praktikant sætter spørgsmålstegn ved en morders motiv for at melde sig som organdonor.

En lam mand får følelsen tilbage i sine ben, hvilket får Melendez til at tro at han kan komme til at gå igen. Andrew må tage sig af et plastikindgreb der er gået galt, for at redde en kvindes liv.

Dr. Shaun tvivler på nødvendigheden for en operation, som vil give hans patient muligheden for at smile. Dr. Claire Brown og dr. Morgan Reznick opdager at deres patient har løjet om sin identitet.

Shaun bliver distraheret over urovækkende nyheder om Glassman, og begår en fejl der kan ende med at ødelægge hans karriere.

Shauns foreslåede behandling af en hjemløs patient bringer ham og Jared i en dårlig position. Clarie vil overbevise Melendez om at udgøre en risikabel hjerteoperation. Glassman træffer et svært valg.

Shaun går mod Melendez for at kunne behandle en meget syg sygehusvagtmester. Samtidig risikerer Lim en stævning i forbindelse med behandlingen af en rituelt omskåret teenagepige.

Clarie konfronterer Andrews angående lægernes udmattende skema og arbejder for at behandle en infertil patient. Shaun lover Glassman at stå ved hans side, mens han kommer sig efter hjerneoperationen.

Shaun mindes sin egen fortid, da han hjælper en teenagedreng. Efter operationen får Glassman hallucinationer og tvinges til at konfrontere en personlig tragedie.

En patient beder Shaun og Park om at hemmeligholde en tidligere vægt-mindskende operation overfor hans partner. Claire og Melendez er uenige om, hvordan de skal behandle en anorektisk kvinde.

Claire bliver venner med en teenage-patient, som mistænkes at lide af stress under forældrenes skilsmisse. Shaun og Morgan er uenige om, hvordan de skal behandle en koncertviolinists skadede finger.

Claire forsøger at lindre en døende klassekammerats smerte, men situationen kompliceres af en uventet forespørgsel. Shaun og Morgan forhandler vilkårene for en transplantation mellem to stædige brødre.

En akut patient bliver tvunget til at afsløre en hemmelighed for sin mand, efter at lægernes behandling har forårsaget problemer.

Melendez, Reznick og Brown kæmper med en patient, som vil gennemgå en operation der kan forhindre ham i at agere på sin pædofili. Samtidig lærer Shaun Murphy en lektie i empati.

Murphy og Park behandler to patienter, der er kollapset i lufthavnen. Alt peger på, at det er en luftbåret infektion, og alle patienter på skadestuen er i fare.

Dr. Murphy bliver overvældet af kaosset på skadestuen. Dr. Reznick kæmper med at holde sin patient i live, mens Dr. Lim kæmper for sit eget liv.

Efter karantænen får personalet på sygehuset en fridag. Da de igen er tilbage, må Andrews parere en forespørgsel fra en ansat på helsedepartementet.

Melendez, Claire og Park kæmper for at redde en kvinde, hvis mekaniske hjerte kræver både ingeniørkundskaber og medicinsk ekspertise.

Dr. Andrews forsøger at overbevise en sørgende familie om at donere deres teenagedatters ansigt til en anden ung pige, som er blevet alvorligt skadet i en ulykke.

Shauns brutale ærlighed mod en mor, hvis baby er i kritisk tilstand får den nye chefkirurg til at sætte spørgsmålstegn ved Shauns kapacitet.

Den nye chefkirurg synes, at Shaun er en større byrde end tilgang, og arbejder for at udelukke ham fra operationsstuen.

Murphy gør nogle desperate forsøg på at få lov at være en del af operationsteamet, da de skal fjerne en hjernetumor fra en patient. Men først må han bevise sit talent i en anden sag.

Melendez og Lim offentliggør sit forhold, samtidig forsøger Glassman at reparere forholdet til sin gode ven.

Shaun foreslår en omfattende operation, der skal redde en kvindes liv. Morgan og Alex strides om at få lov til at operere en patient, der har fået konstateret kræft.

Shaun udfører en eksperimenterende kæbeoperation. Debbie opfordrer Aaron til at involvere sig mere i Shauns kærlighedsliv.

Claire forbereder sig på sin første operation, men står overfor en udfordring. Personalet skal behandle en lystfiskers skader uden at beskadige hans fangst.

En konspirationsteoretiker insisterer på, at hans forestående leveroperation skyldes forgiftning. Claire, Morgan og Neil behandler en kvinde med en sprængt blindtarm.

Shaun får sin første opgave som førstekirurg. Aaron opdager noget om Debbie, som får ham til at tvivle på deres forhold.

Shaun distraheres forud for en blindtarmsoperation. Alex og Neil forbereder sig på en vanskelig operation. Aaron må træffe en svær beslutning om en ansættelse.

Neil og Claires nye patienter tvinger dem til at konfrontere deres egen sorg. Debbies arbejdsstil sætter Aaron på prøve.

Carlys romantiske bejlen til Shaun frustrerer dem begge. Imens kæmper Audrey og Neil med at adskille arbejdsliv fra privatliv.

Shaun forbereder sig på næste skridt i forholdet til Carly. En ung patient må tage stilling til en potentielt skelsættende behandling.

Shaun besøger sin far, der er alvorligt syg. Imens behandler Neil, Alex, Morgan og Claire en fodboldspiller med skadet rygrad.

Shaun kæmper med sine følelser for Carly og Lea. Claire trækker på sin egen fortid. Marcus skal operere en kvinde, som nægter at lade sig bedøve.

Carly og Shaun behandler en ultramaratonløber med en mystisk sygdom. Claire hjælper en teenager, hvis hjernetumor er vendt tilbage.

Spændingerne i familien tager til, da Morgans mor ankommer til St. Bonaventure. Shaun indser, at der stadig er noget at arbejde på i forhold til Carly.

Shaun har muligvis udsigt til berømmelse. Claire, Alex og Neil behandler en mor og datter med en overraskende forbindelse.

Neil bliver anklaget for at have favoriseret sit eget hold, og Shaun foreslår en nyskabende form for kirurgi, som skal hjælpe en ung dreng, der ikke kan tale.

Shaun dedikerer sig atter til arbejdet, og Claire og Morgan går sammen for at behandle en universitetsstuderende med neurologiske symptomer.

Shaun forfølger Lea. Alex forsøger at genetablere kontakten til sin søn. Teamet tilser en ung kvinde med mystiske symptomer.

Shaun kæmper fortsat med sit personlige tab, og Morgan står overfor et svært karrierevalg. Marcus og Audrey er splittede over en patients ønsker.

Da et jordskælv rammer det lokale bryggeri, presses hele teamet på St. Bonaventure til det yderste for at redde deres patienter – og deres kollegaer.

Lægeholdet arbejder om kap med uret for at redde liv, og i denne sæsonafslutning kommer deres personlige sikkerhed på spil.

Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.

With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery. And elsewhere, Dr. Morgan Reznick seeks out Claire and Lim’s help on a consult.

Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations

Dr. Shaun Murphy questions his decision to give the new residents autonomy when one of his intern's misdiagnosis of a patient has dire consequences. Meanwhile, Dr. Claire Browne, Dr. Alex Park and Dr. Jordan Allen treat a patient with a ruptured cyst affecting key functions of her brain. And elsewhere, Dr. Morgan Reznick and Park bond over failed relationships.

As Chief of Surgery Dr. Audrey Lim struggles to cope with the residual emotional trauma of COVID-19, she encounters a young war veteran fighting debilitating PTSD. After discussing his case with the team, Dr. Claire Browne suggests a radical treatment to help him. Meanwhile, still reeling from the recent loss of his mentee’s patient, Dr. Shaun Murphy declares he doesn’t want to teach the new residents anymore. And elsewhere, an eccentric patient keeps the team entertained.

Dr. Morgan Reznick discovers her patient’s wealth and obsession with extending his life is a dangerous mix that could end up costing more than he can afford.

The team treats a teenage gymnast who experiences complications from her intensive training. Meanwhile, Shaun meets Lea's parents for the first time.

Lim is challenged by the unique circumstances surrounding a pregnant patient with an aggressive tumor. Elsewhere, after misdiagnosing a patient, Claire makes a disconcerting discovery about certain practices at the hospital.

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

After bringing in an incredibly unique and complicated spinal surgery, Dr. Aaron Glassman challenges the residents for an opportunity to join him in the operating room. Meanwhile, Shaun and Morgan disagree on how to treat a comatose patient with a cancerous tumor.

When a renowned surgeon comes to St. Bonaventure for treatment, the team’s enthusiasm is quickly overshadowed by the doctor’s behavior. After studying his case, Dr. Shaun Murphy sees a pattern he recognizes. Meanwhile, Shaun and Lea are forced to make a life-changing decision that will alter the course of their relationship.

Claire is blindsided when her absentee father shows up at her door. Meanwhile, Shaun feels disconnected from Lea, causing tension in their relationship.

After finding out the gender of their unborn child, Lea's enthusiasm prompts Shaun to make an effort to be a more supportive partner. Meanwhile, the team treats a navy pilot whose previous doctor's misdiagnosis compromises her chances at a full recovery.

After a political protest turns violent, the team races to save two young gunshot victims.

Shaun struggles with his role as Lea's partner after complications arise with the pregnancy and his instincts as a medical professional kick in. Meanwhile, Dr. Park, Dr. Andrews and Asher disagree on how to address an elderly patient's wishes.

Dr. Claire Brown and the team must face hard truths about what lines they are willing to cross when one of Claire's idols becomes her patient.

Shaun and Lea go on a camping trip to distract themselves from their grief over their miscarriage. Meanwhile, Morgan and Park argue about the best course of treatment for their patient.

The St. Bonaventure team travels to Guatemala on a surgical mission to help patients at a rural hospital. Once there, the team faces a small community that is in desperate need of their help but are assigned the daunting task of identifying who they can help most. And while Shaun seems to be thriving in Guatemala, Lea is still struggling with the loss of her baby.

Dr. Shaun Murphy must perform a risky surgery on a patient without electricity when the power suddenly goes out. Meanwhile Lim and Dr. Mateo Rendón Osma’s relationship deepens as they overcome difficulties during the surgery.

Shaun and Lea's upcoming engagement party has everyone in a festive mood; a young single mother learns her son may have contracted his cancer from a surprising source; Mateo finds out if his previous issues in America will be resolved.

Dr. Shaun Murphy and the team race to save a pregnant woman's baby and find her current situation as a convicted felon complicates it even more than they realize. Meanwhile, the hospital takes on some unexpected changes that the staff are not prepared for.

Shaun confronts Salen about the many changes she has implemented since coming on at St. Bonaventure. Glassman is forced to accept his new role at the hospital.

Dr. Shaun Murphy and the team treat a young girl whose father’s personal research complicates their treatment plans. Meanwhile, Dr. Park, Dr. Reznick and Dr. Lim’s patient refuses a life-saving lung transplant despite having a family donor.

Dr. Park and Dr. Murphy treat an elderly Asian man brought to St. Bonaventure by his daughter after being the victim of a hate crime. In addition, Lea goes behind Shaun’s back to help raise his negative patient satisfaction scores.

Dr. Shaun Murphy and Dr. Alex Park must grapple with a life-and-death decision and decide between saving one patient over another. Meanwhile, Dr. Morgan Reznick goes a little too far in her attempt to win Salen’s favor.

Shaun and Lea happen upon a terrible car accident and discover a young pregnant mother who has been badly injured and needs immediate medical attention. Dr. Glassman is apprehensive when a figure from his past reaches out for help.

Now that Shaun has called off the wedding, he is forced to confront Lea about their relationship and determine what he really means to her. Meanwhile, the team debate their opinions on plastic surgery and Dr. Audrey Lim hopes to expose Salen’s cover-up over an infant’s death to take her down before it is too late.

In an effort to please Salen, Andrews takes on a high-profile case and assigns Shaun and Allen to help perform a risky surgery to restore the voice of a famous pop star.

Salen takes extreme measures when she learns that the surgical staff have joined Lim's efforts against her. The team treats a liver transplant patient whose organ donor unwittingly gave him cancer.

Dr. Shaun Murphy makes a personal connection with a precoious young patient which threatens his objectivity. Meanwhile, while volunteering at a long-term care facility, Dr. Morgan Reznick realizes she could help Dr. Aaron Glassman’s clinic by offering telemedicine services for nursing homes and care facilities.

Drs. Lim, Park and Wolke treat a woman with Valley fever and discover a secret she has been hiding from her fiancé. Meanwhile, Drs. Murphy, Allen and Andrews treat a 45-year-old virgin and help her make a big decision about her life.

While Drs. Lim, Murphy and Wolke help a teenage “biohacker” whose self- experiments begin to compromise his health, Drs. Morgan, Park, Jordan and Glassman treat a young woman who wants a controversial surgery to treat her depression and chronic pain. Additionally, Dr. Reznick looks to take the next step in her relationship with Dr. Park.

When someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck, much of the hospital staff and doctors are incapacitated -- leaving doctors Murphy, Glassman and Allen forced to take on all the hospital's cases, further exacerbating Dr. Murphy and Dr. Glassman's conflicting work styles.

While Doctor Andrews treats a foster kid for injuries sustained at his group home, Shaun and team look to Lea's expertise with cars and auto repair to help a patient whose iron lung has broken. Meanwhile, the patient's niece, a documentarian, takes an interest in Shaun.

As Shaun and Lea head toward their wedding day, a documentary film maker has chosen to follow their lives to showcase relationships and weddings of atypical couples.

Sophie takes Lea out for a day full of luxurious wedding planning. And after a near fatal oversight, Dr. Lim senses an underlying issue is behind nurse Villanueva's unprofessional behavior.

Shaun and Lea make a big life decision and are pleasantly surprised by the support they receive from their friends at the hospital. Meanwhile, when Dr. Wolke's parents show up with a revelation, Asher struggles to accept that he and his father may never truly understand one another.

As the doctors consider their futures, they work together to solve one of the most important cases of their careers.