In 1958 New York, Midge Maisel's life is on track- husband, kids, and elegant Yom Kippur dinners in their Upper West Side apartment. But when her life takes a surprise turn, she has to quickly decide what else she's good at - and going from housewife to stand-up comic is a wild choice to everyone but her.

Midge's life is in a tailspin in the wake of Joel leaving. Midge and Joel's parents butt heads while trying to keep their family together. Susie pushes Midge to get back on stage and find her voice.

After another arrest, Midge finds herself in legal trouble, forcing her to rely on Susie's street smarts. Abe approaches Moishe with an interesting proposition. Lenny Bruce offers some unconventional inspiration for Midge's act.

Midge begins to move on from her once perfect life. Susie shows Midge the ropes while going on a tour of New York comedy clubs. Rose takes a bit too much pleasure in Midge's new living arrangements.

Midge dives into a new line of work and makes some quirky friends along the way. Susie continues her emphatic quest to keep Midge's career moving forward, but gets hit with a couple setbacks. Both Midge and Joel experience the downsides of their new lifestyles.

Midge finds a different kind of audience to perform for, much to Susie's chagrin. Abe gets offered the experience of a lifetime. The Weissmans come together for a family dinner. Susie finally shows off her management skills.

With Susie's help, Midge hones her act at the Gaslight. Abe surprises the women with a dinner guest, sending Rose into an emotional spiral. Working towards a promotion, Joel conjures up a new plan. Midge stirs up controversy after meeting a big-time comedian.