A junior doctor becomes disillusioned with her life and decides to leave the UK. She heads for South India hoping to make a fresh start, and finds a new home working in an under-resourced and over-worked cottage hospital run by an eccentric English ex-pat.

The team race against the clock to treat a local snake catcher.

As Holi festival fever hits The Good Karma Hospital, an abandoned baby strikes a personal chord with Ruby. Meanwhile, Lydia is reacquainted with an aging ex-pat artist, whose alternative life choices may be about to catch up with him.

On the day that he is attending a lavish Indian wedding, Ram clashes with Lydia when a medical case gets personal. Meanwhile, as Ruby treats a patient from the UK whose story doesn't quite add up, she's left questioning where she truly belongs.

As the first monsoon rains arrive, tensions run high between Lydia and Ruby leading Ruby to make a shock decision. Meanwhile, Maggie's health is rapidly declining, and with her daughter insisting on returning to the UK, will Maggie be granted her dying wish to stay in India?