Edie is shocked when she receives some news at the gynecologist's office. At the baby shower Bree's friends throw her, Bree's ex-mother-in-law Phyllis discovers her pregnancy is a hoax. Finally, Wisteria Lane welcomes to the street a homosexual couple.

Bob & Lee's contemporary water sculpture in their front yard prompts the Wisteria Lane neighborhood association into action. Edie finds out about the affair that Carlos is having with Gaby. Also, John Rowland wants to rekindle his romance with Gaby.

This is the show's first Halloween episode. Edie Britt's biggest fear comes true when Carlos walks out on their relationship. Susan finds Mike's father, who was supposedly dead. Danielle goes into labor right in the middle of the Halloween party... and somebody has to deliver the baby.

In the aftermath of the tornado, the residents of Wisteria Lane try to rebuild their lives. Katherine discovers someone may know her secret while Lynette faces the possibility of her family's fate.

Susan meets her ex-husband, Karl at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Meanwhile, Gabrielle rents a room to a hip artist, Ellie, who has a dark secret. Elsewhere, Dylan continues meeting with her father, Wayne, and Katherine decides to go spy on her.

Susan and Mike try to name their son. Lynette is arrested for supposedly attacking Kayla, and Tom must do what he can to save his family. Bree is being stalked by Orson, and when she meets with Reverend Green, the reverend tries to hit on her. In the meantime, Gabrielle is still helping the police trying to detain Ellie for dealing drugs. Finally, Katherine is visited by her ex-husband, Wayne.

Five years have passed since Katherine shot her ex-husband as Susan, Lynette, Bree and Gaby stood together in solidarity to protect her. Susan tries to hide her relationship with a new man; Gaby questions her abilities as a mom; Bree is on the verge of publishing her own cookbook as business partner, Katherine, grows envious; Lynette catches her teenaged twins spearheading illegal activities; and Edie returns to Wisteria Lane in jaw-dropping fashion with a new man in tow.

Bree treats herself to a new car; Susan wants to send M.J. to the best school even though she and Mike can't afford it; Gaby tries to get back into shape; Lee wonders if he should tell Tom and Lynette some disturbing facts about Dave.

Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey's decision to tell the police that she saw Angie Bolen's 19-year-old son, Danny, fighting with Julie.

A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland; Bree contemplates a weekend getaway with Karl; Lynette and Tom break the news to their kids that she's pregnant again; and Susan is convinced Angie's son is responsible for her daughter's attack.

When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent. Bree gets defensive when she’s judged by a motel maid for having an affair with Karl. Lynette is put off by her new handyman when he defers to Tom for approval on all things and Susan and Katherine come to blows over Mike.

Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.

Susan discovers a surprising connection between Mike and Katherine, which leads her to question her relationship with Mike. Meanwhile Gaby will stop at nothing to get Juanita into Catholic school, and Lynette's pregnancy becomes hysterically impossible to hide. Meanwhile, as Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree's imperfect marriage.

Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.

Lynette balks at the idea of seeing a couples' therapist. Meanwhile, Katherine is seeing her own psychiatrist, Gaby and Susan are determined to find out which of if their kids are in the smartest group at school, and Angie disapproves of Danny's new girlfriend.

While in the Big Apple, a chance encounter with supermodels Heidi Klum and Paulina Porizkova leads Gaby to an unexpected revelation about herself. Meanwhile, Lynette and Tom are in for a big surprise when Preston returns from Europe; Mike is determined to show Susan what a man he is after feeling emasculated; Bree discovers a shocking connection to her new employee, Sam; and Katherine is confused over her feelings for Robin.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.