The new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Rex's mother arrives on Wisteria Lane for his funeral. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

Susan is surprised when she finds out who Edie's new boyfriend is. Meanwhile, Lynette has gone back to work, leaving Tom at home in charge of the house. Carlos makes an unusual request to Gabrielle after his life is threatened behind bars. Lastly, pharmacist George reemerges in Bree's life, which sets off an alarm to mother-in-law Phyllis and her suspicions surrounding her son's death.

Susan tries bravely to accept Edie’s new role in Julie’s life, while Lynette’s demanding boss makes her miss Parker’s first day of kindergarten. Bree later on takes a polygraph test to prove her innocence in Rex's death and realizes she has feelings for George.

Gabrielle finally comes to the truth about Carlos and John after seeing John with another woman.

Susan's longtime book agent and dear friend, Lonny Moon gets into financial trouble. Lynette is forced to go out to bars night after night with her man-hungry boss, Nina. Bree finds out about Rex's feelings about her prior to his death. Lastly, Gabrielle hires hotshot lawyer David Bradley to defend Carlos in court but Carlos rejects him after he witnesses an attraction between David and Gabrielle.

Mike and Susan face a crisis in their relationship when Susan tries to get Paul Young arrested by confessing to a police officer that he killed Mrs. Huber and Mike has her diaries as proof. The officer goes over to Mike to get the story, but Mike denies the whole thing. As Carlos continues serving his jail sentence, Gabrielle valiantly tries to free him. Bree goes to a romantic hotel with George, but requests they sleep in separate rooms.

George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.