Looking down on her friends and family isn't a way of life for Mary Alice Young. It's a way of death. One day, in her perfect house, in the loveliest of suburbs, Mary Alice ended it all. Now she's taking us into the lives of her family, friends and neighbors, commenting from her elevated POV. Her husband's acting suspicious, the neighbors are talking, and her girlfriends are wondering why one of their own would do something so rash… and so messy.

Mike's dog pays the price when Edie crashes his dinner date with Susan. Meanwhile, Gabrielle realizes that her lawnboy is taking their fling to heart - and that Carlos may actually be catching on. Also, Bree goads Rex into therapy, where the doctor may be the one who needs the most help. Lynette resorts to drastic measures to keep her kids in line, but it blows up in her face.

The women decide to go ahead with the big dinner party that the late Mary Alice Young had planned to host, despite the more-than-minor disturbances in their own lives. Adulterous Gabrielle finds herself with a nine-year-old blackmailer who catches Gabrielle in the act in her affair with gardener John. Also, Bree struggles to keep her crumbling marriage a secret. Lastly, Susan bares all--in more ways than one--as she confronts her ex.

Cash-strapped Mrs. Huber figures out that Susan had something to do with Edie's house fire and tries to blackmail her. Meanwhile, Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect---the cable guy instead of gardener John. Also, Lynette balks when the twins' teacher insists the boys have ADD but tries to salvage the matter by seprating the boys. Lastly, Bree struggles with her rebellious son Andrew after Rex moves out.

Susan and Edie decide to follow Mike and his houseguest Kendra on their night out together. Lynette becomes steadily more dependent on the twins' ADD medication. In the meantime Gabrielle becomes jealous of the "other" woman in John's life. And Bree's kids mutiny when they learn their dad has moved out. Tom is not happy when Lynette tries to take over his concept of new "Spotless Scrubs" to his clients.

In the aftermath of tragedy with Bree's son Andrew running over Carlos' mother Juanita Solis, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike's real reason for moving to the street. Lynette reaches the breaking point in her addiction to the twins' ADD medication as she tries other measures like acupuncture to release her stress. The mysterious Mr. Shaw gets down to business as he develops a relationship with Edie. Lastly, Gabrielle confesses her adulterous affair to a priest while Carlos' mother Juanita is in the hospital.

Edie organizes a neighborhood search for the missing Mrs. Huber, just as the absent busybody's sister Felicia Tilman arrives on Wisteria Lane. Meanwhile, Bree resigns herself to her marital state and asks an attractive pharmacist on a date. Susan's ex Karl suddenly reappears in her life, and Lynette fears that Tom is attracted to the new nanny. Lastly, Gabrielle sinks to new depths.. she gets a job.

The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

When Eli Scruggs (Beau Bridges), the neighborhood handyman, passes away, the residents of Wisteria Lane realize how much he affected their lives.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.