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Säsong 1 av Desperate Housewives hade premiär den 3 oktober 2004.

Mary Alice Young, a seemingly perfect housewife commits suicide, fearing that a dark secret, involving her, her husband, and their son would be exposed.

Säsong 2 av Desperate Housewives hade premiär den 25 september 2005.

The seemingly perfect lives in the suburban neighborhood of Fairview are shaken by the arrival of the mysterious Betty Applewhite.

Säsong 3 av Desperate Housewives hade premiär den 24 september 2006.

The residents of Fairview deal with the arrival of the mysterious Orson Hodge.

Säsong 4 av Desperate Housewives hade premiär den 30 september 2007.

Katherine Mayfair and her family are introduced as the center of the season's mystery.

Säsong 5 av Desperate Housewives hade premiär den 28 september 2008.

The season's mystery is centered around Edie Britt's third husband Dave Williams.

Säsong 6 av Desperate Housewives hade premiär den 27 september 2009.

Angie Bolen and her family are the focus of this season's mystery.

Säsong 7 av Desperate Housewives hade premiär den 26 september 2010.

After losing both her husband and her business, Bree slowly begins the process of rebuilding her life, first by telling her friend Gabrielle a secret that could end their friendship, and then by starting up a romance with her much younger contractor Keith Watson. In the meantime, the Solises discover that their daughter Juanita was swapped at birth, and Lynette is visited by her old college roommate Renee Perry (Vanessa Williams), who later moves to the lane permanently. Bob and Lee find their way back to one another, and Susan and Mike's financial situations lead them to move to an apartment in the city and to take on jobs they don't want to endure through, whereas Paul Young, Mary Alice's widower, moves back to Wisteria Lane to wreak havoc.

Säsong 8 av Desperate Housewives hade premiär den 25 september 2011.

The housewives deal with covering up the murder of Gabrielle's stepfather Alejandro Perez.