Als Susan erfährt, dass Zach Mikes Sohn ist, weiß sie zunächst nicht, wie sie damit umgehen soll. John macht sich derweil Hoffnungen, dass seine Beziehung zu Gabby eine Zukunft haben könnte. Doch die will lieber einen Neuanfang mit Carlos wagen.

Susan is surprised when she finds out who Edie's new boyfriend is. Meanwhile, Lynette has gone back to work, leaving Tom at home in charge of the house. Carlos makes an unusual request to Gabrielle after his life is threatened behind bars. Lastly, pharmacist George reemerges in Bree's life, which sets off an alarm to mother-in-law Phyllis and her suspicions surrounding her son's death.

Phyllis hat Rex' Leiche exhumieren lassen, da der Verdacht besteht, er sei vergiftet worden. Bree erfährt erst davon, als sie vor Rex' leerem Grab steht. Susan ist eifersüchtig auf Edie, da diese Julie zu einer Talentshow in der Schule begleiten will.

Susan's longtime book agent and dear friend, Lonny Moon gets into financial trouble. Lynette is forced to go out to bars night after night with her man-hungry boss, Nina. Bree finds out about Rex's feelings about her prior to his death. Lastly, Gabrielle hires hotshot lawyer David Bradley to defend Carlos in court but Carlos rejects him after he witnesses an attraction between David and Gabrielle.

Lynette möchte eine horrende Summe für ein schickes Kostüm ausgeben, das sie bei einer Präsentation in der Firma tragen will. Tom ist jedoch strikt dagegen. Bree und George sind derweil mit einem Problem konfrontiert: Jedes Mal, wenn George sich Bree nähert, bekommt diese einen juckenden Ausschlag.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavos learn more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.

Lynette tries to put a daycare center in Parcher & Murphy by recruiting employees' children to get the program started. Gabrielle and Sister Mary Bernard face off over Carlos' mission of mercy to Africa. Bree brings Andrew home and tells him about the revelation of George poisoning his father Rex and killing him. Lastly, Susan confronts her biological father's wife after she thinks they are having an affair.

Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.

After a number of bad dates, Susan finally meets Dr. Right. Susan flirts with a handsome doctor, but they accidentally head butt. Meanwhile, some old pictures of Gabrielle turn up on the Internet. Tom is alarmed when his kids come down with chicken pox because he never had it. Bree gets arrested. Lastly, after months of silence, Noah Taylor contacts Mike Delfino.

Dr. Ron informs Susan that she needs a splenectomy. Gabrielle and her arch-enemy Sister Mary Bernard finally face off in church.

Also, Tom decides to apply for an empty position at Lynette's job, which leads to the arousal of past issues in their marriage. Lastly, Matthew and Danielle's relationship is found out by both their mothers, which leads to big repercussions later on for Bree and her past secret with Andrew last year.

Tom versucht, sich bei seinem Chef Ed einzuschleimen, merkt jedoch nicht, dass sein Vorhaben nicht gut ankommt und Ed ständig Witze über Tom reißt. Lynette findet schnell einen Weg, Ed davon abzuhalten. Susan ist derweil verzweifelt: Sie braucht dringend eine Krankenversicherung für ihre bevorstehende Milz-Operation.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Um Dr. Ron zu beweisen, dass ihre Ehe mit Karl rein zweckmäßig ist, organisiert Susan ein gemeinsames Abendessen. Diese Idee geht jedoch mächtig nach hinten los. Derweil macht Gaby sich auf die Suche nach einer geeigneten Mutter für ihr Adoptivkind.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

Gabrielle and Carlos are shocked when the father of their baby shows up to take the baby back. Cops and a lawyer arrive to a house on Wisteria Lane. Lynette tries to help Ed heat up his sex life. Meanwhile, Karl decides to break up with Edie, as Edie has no idea that Susan is the "other woman." Edie causes a fight to break out in a bar, after she trips a waitress. Lastly, Bree is taken a step forward to help Peter when she finds out how bad his other addiction is.

Um ihr Gewissen zu erleichtern, schreibt Susan Edie einen Brief, in dem sie das Techtelmechtel mit Karl gesteht. Sie ahnt nicht, dass Mike den von Edie engagierten Privatdetektiv bezahlt hat, um ihr Geheimnis zu bewahren.

Reaching the end of her rope, Bree checks herself into the Fairview psychiatric hospital. Lynette suspects that Tom is cheating on her, so she follows him to Atlantic City. Susan must start over. Felicia Tilman has more in store for Paul Young, resulting in their war reaching its final battle. Gaby and Carlos get Xiao-Mei pregnant.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.