Susan and Edie decide to follow Mike and his houseguest Kendra on their night out together. Lynette becomes steadily more dependent on the twins' ADD medication. In the meantime Gabrielle becomes jealous of the "other" woman in John's life. And Bree's kids mutiny when they learn their dad has moved out. Tom is not happy when Lynette tries to take over his concept of new "Spotless Scrubs" to his clients.

The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.

Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Lynette's marriage takes a dramatic turn after an upset Tom vows that it is now her turn to go back to work and he'll be staying home with the kids. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him.

On one of Gabrielle's prison visits to see Carlos she creates a terrible riot, which lands Carlos in hot water. Also, Susan puts her feelings aside and joins Mike in searching for his son Zach. Lynette is surprised to find out that her son Parker has an imaginary friend. Lastly, George and Andrew both vie for Bree's attention as they both compete in making each other look bad in front of her, until one fight goes a little too far.

Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.

Während Susan mit Ian auf der Berghütte ist, erwacht Mike aus dem Koma. Edie nutzt diese Situation zu ihrem Vorteil aus, da Mike jegliche Erinnerungen aus den vergangenen zwei Jahren fehlen.

Ian proposes to Susan. The Scavo pizzeria prepares for its grand opening. Mike visits a hypnotherapist in hopes of remembering Monique. Gabrielle's romantically interested in a lawyer, but he's working for Zach who wants her for himself. Bree is hospitalized after a fall, after being tricked to climb on a ladder to retrieve Monique's teeth.

Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.

Bree informs the housewives of what she overheard in the Mayfair house. Stella makes some special brownies to help Lynette through chemotherapy. Susan throws a charades party for the whole neighborhood.

A tornado comes to Wisteria Lane, forcing residents into basements, cellars and safe rooms, and destroying homes and lives. Meanwhile, Susan ends up at the hospital after falling down the stairs.

Bree's new found success causes the rest of the women on Wisteria Lane to feel envious. Lynette longs to return to her days as an ad-executive, and finds an outlet as Bree's marketing manager. Mike feels that he is not a big enough presence in his son's life after M.J. draws a family portrait and leaves him out. Meanwhile, Gaby comes up with a way to have more sex with Carlos.

Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday. Jackson wants to take his relationship with Susan to the next level. Gabrielle's concerned she might be pregnant. Tom tells Lynette he's sold the pizzeria. A startling reason for the bond between Bree and Katherine is revealed. And finally, an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.

Gabrielle zieht wegen Celias Windpocken vorübergehend zu Bob und Lee, mit denen sie die Nacht zum Tag macht. Ein Zurück nach Hause ist für sie bald nur noch schwer vorstellbar.