Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a great American folk art.

Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.