Bryan Mills fights for his life inside a secret Mexican prison and plans a series of dangerous deals to put him on track for escape to the United States. But plans change when Mills and a young migrant girl are taken by human traffickers. Meanwhile, Christina Hart leverages her spycraft skills to obtain powerful new software that could locate Mills, and enlists two unlikely allies to aid in her mission to bring Mills home.

When a plane crashes carrying Bryan Mills and a key witness in a murder investigation, a wounded Mills must call upon the survival skills his father taught him to overcome the elements, find a way out of the woods and protect the witness from a lethal team of mercenaries on their tail. Meanwhile, Santana organizes a 'go big or go home' plan to locate the downed plane.

When the President's emergency "football" is stolen, Bryan and the team must recover it before classified national security measures fall into dangerous hands.

Santana terpaksa mengingati masa lalunya apabila seorang diplomat asing yang dikaitkan dengan kumpulan pemerdagangan seks diculik.

When the wife of a war hero senator is taken, Bryan and the team must determine if her disappearance was orchestrated by a foreign government or someone closer to home. Meanwhile, Christina's meeting with an old friend brings up painful memories.

Bryan and Santana must extract a nuclear physicist long thought dead, from a secret North Korean prison compound. Meanwhile, Kilroy faces a moral dilemma when Hart asks him to locate a criminal wanted by a foreign government.

Hart takes a solo mission to track down the mentor who betrayed her, and the team tries to locate her before it's too late.

Hart must find a way to stop an exiled former journalist from leaking the names of government assets abroad before innocent lives are taken.

Bryan must stop an act of biological terrorism when invasive species are stolen from the Global Seed Bank in Norway.

When a bomb goes off in Washington D.C., the team suspects an innocent man is being framed for the crime. Meanwhile, Kilroy tracks down a notorious hacker.

Apabila seorang peniaga senjata berbahaya menyeludup barangannya ke Kota New York, Bryan bekerjasama dengan FBI dalam usaha menghalangnya sebelum dia tiba di pemeriksaan keselamatan perairan antarabangsa.

Apabila anak seorang penganalisis CIA diculik, pasukan itu mendapat bantuan daripada sumber yang tidak disangka-sangka - seorang lagi mangsa penculikan.

Bryan mesti melindungi sepupunya apabila dia menjadi sasaran sindiket jenayah yang berkuasa.

The daughter of a government official working overseas is taken, and an unexpected suspect derails Bryan's rescue operation.

With Hart in grave danger, the team must find their own way to stop Ramsey before his plan to assassinate a senator starts a war with international terrorists.