汤姆是超级英雄团队“神奇熟人”（模仿《恐龙战队》）的宠物，负责守护他们的能量戒指。然而，当杰瑞进入存放戒指的房间时，他和汤姆最终进行了一场超能力的决斗。更糟糕的是，熟人的宿敌末日狗（斯派克饰）在不被发现的情况下闯入藏身处，想要将所有戒指据为己有。汤姆和杰瑞必须齐心协力，汇集火与冰的力量，才能打倒恶棍。英雄们祝贺汤姆捕获了末日狗，但杰瑞在增长动力戒指的帮助下，不那么温和地提醒他，他并不是独自完成这件事的。

杰瑞被高速射线击中，速度比以往任何时候都快。

汤姆和杰瑞掉进了一个花园洞，他们在那里找到了一个地下室总部。

佛教僧侣汤姆试图实现内心的平静。

斯派克作为精灵，必须实现愿望。

汤姆必须获得一只老鼠来获取女巫的魔药。

汤姆在学校参加表演和讲述活动。 1943 年动画片《小猫》中的南希回归，因为她想赢得最佳宠物金星奖。

杰瑞和塔菲试图破坏汤姆参加猫展的机会。

汤姆的主人聘请了一名训练师来训练他的行为。

杰瑞和一只逃跑的企鹅成为了朋友。

饥饿的汤姆试图抓住杰瑞并吃掉杰瑞，杰瑞和一只老鹰一起成为当地海洋主题公园的明星，但他遭到老鹰、海豹和章鱼的阻挠。

杰瑞和小犀牛成了朋友。

一艘绿色变形者从一艘降落在汤姆和杰瑞家附近的外星飞船中出现。

著名的传奇怪物猎人范海辛和他的助手汤姆在一家酒店停下来，那里正在举办怪物大会。在那里，猫使用范海辛的一些设备试图抓住杰瑞，但他却抓住了一些鬼魂。后来，汤姆被狼人咬伤并变成了黑豹，这使他成为范海辛的目标，范海辛误认为他是狼人猫，并试图将他添加到他的收藏中。

汤姆和杰瑞在闹鬼的森林中迷路，布奇作为一只蝙蝠（与汤姆大小相同）告诉他们只有一个人可以逃脱。布奇利用这个机会逃跑，而汤姆和杰瑞则试图比他跑到出口。

杰瑞打扮得像个滑板运动员，试图从冰箱里拿食物。随后，他追赶一辆载有奶酪的卡车，而汤姆则骑着一辆越野车紧追不舍，后面还跟着狂欢。

汤姆在当地泳池与德鲁比竞争救生员的角色。

在一次露营旅行中，汤姆、杰瑞和塔菲遇到了传说中的大脚野人 - 它恰好是一种大脚、矮小但友善的生物，名叫谢尔顿。

双鞋太太指派汤姆把所有害虫（包括杰瑞）赶出花园，但这项工作对猫来说相当复杂，因为杰瑞有很多与他相似的人（他们都戴着不同颜色的头巾）。

布奇邀请汤姆加入猫联盟，这是一个秘密组织，该组织相信通过联合起来对抗老鼠可以更有效地捕捉老鼠。杰瑞组织了老鼠联盟，其数量超过了猫。

在一场残酷的热浪中，当汤姆和他的主人“双鞋太太”在冰箱旁休息时，杰瑞带着所有的食物去野餐，这让猫因盗窃而受到谴责，并被赶出家门。汤姆在蚂蚁的帮助下设法进行报复。

汤姆的踢足球动作惹恼了斯派克和杰瑞。寻找《Flirty Birdy》中鹰的客串，以及对《Fit to Be Tied》中经典皮带笑话的致敬。

汤姆、杰瑞和德鲁比参加冲浪比赛。令所有人惊讶的是，德鲁比赢得了巨额现金奖励。汤姆以微弱优势击败杰瑞获得第二名，并赢得了终身供应的奶酪！

网球冠军汤姆在父亲的要求下试图教泰克打球。但是，他很累，发生了很多灾难。当汤姆使用投球器时。杰瑞把球调得很快，球传给了汤姆，他全命中了。直到最后一个球弹出，它击中了泰克的鼻子，让他哭了，他的父亲把汤姆变成了网球拍。然后，杰瑞将球拍绑在泰克的尾巴上，泰克击球，他的父亲进行了最后一击，但他没有击中球。斯派克很高兴他的儿子有技巧，并将汤姆变成了一个球，他们一直在玩。

Just after Thomas Jefferson writes the Declaration of Independence on July 4, 1776, Tom proceeds to lose it by making it into a paper airplane when throwing Jerry out of the house. Jefferson sends the cat out to retrieve it, but as usual, the mouse and Redcoat dog Spike make the task difficult for him.

A museum tour mouse tells young mice about Jerry's role in the Wright brothers' aerial experiments, leading to the historic first flight in Kitty Hawk, North Carolina in 1903. Tom plays his own role courtesy of the duo's usual chases.

Tom and Butch travel back in time to the 19th Century at a Sutter's Mill, Tom and Butch scheme to steal the gold from Jerry's claim, by digging a hole into the pond, which ends up becoming a geyser that leads them into a junkyard filled with spiky thorns, and trying to stop him once he collects the gold. But in the end, they are foiled by their own bad efforts which lead them to be tossed into jail by Sherrif Spike while Jerry becomes a very wealthy mouse.

On a cold winter day, Jerry decides to freeze the pond go ice skating. But Tom wants to play hockey and attempts to engage the little mouse in a physical confrontation.

A truckload of spilled magic hats bring Tom and Jerry's army of snowcats and snowmice to life. The whole opening scene is likely an homage to Chuck Jones' "Bugs' Bonnets". The wizard's hats may be a nod to the Harry Potter franchise.

Tom and Jerry encounter a giant abominable snowmouse during a chase in a forest in the winter. The creature begins to chase them as well, but when he's exposed to hot springs, it shrinks down to size and the duo literally blow the puffy-furred mouse away.

The episode is an updating of the classic Tom and Jerry film The Zoot Cat (1944); it also has some elements of Solid Serenade (1946), with Tom wooing a female cat by singing and accompanying himself on strings. Tom is drawn the way he looked in the films from that period, and the episodes featured the same girl cat (Sherkie), though modernized. Tom now sings to her with a guitar, and in 1950s style blues. He is more interested in pursuing Jerry than in the girl, however, and wrecks the house during the chase which leads him and the mouse to getting the boot in the end.

In old Spain, Tom enters a Flamenco dance contest to try to win the top prize of the Golden Guitar awarded by El Presidente himself. However, this disrupts Jerry's date and he tries to sabotage the cat's efforts to win. But the two, along with their girlfriends vie in a danceoff and Tom wins by bringing the house down--literally!

Tom and his owner go on a safari in Africa where he gets to meet his fellow felines, the wild lions. However, the encounter is less than friendly as instead, Tom and Jerry are chased by the lions who desire to make a meal of them.

When Tom and Jerry travel to Australia, Jerry is able to blend in with a family of kangaroos after being chased by Tom, who schemes to get the mouse away from their mother by any means possible.

Fed up with Jerry in the house, Tom and his owner move to Malaysia. They are touring the exotic monkey garden when Tom finds out Jerry followed them so he throws him down the river and gets gumballs as a reward. Meanwhile, one mischievous monkey swipes the woman's purse. She orders Tom to get it back for her, but not before he goes through its various contents, which leads to more trouble, including going for a joyride in her car and using her cell phone to make a long distance order for pizza.

In a twisted alternate reality, mice chase cats and Jerry's owner orders him to get Tom out of the house by whatever means possible. But in reality, it's a virtual program in which Jerry gets to live his dream. Afterward, Tom tries out a program in which he gets to chase a fearful Spike around.

Tom and Jerry babysit their nephews for the day, which leads to more trouble than usual courtesy of their being very mischievious.

Tom and Jerry go fishing and are pitted against Butch in the form of a catfish, who wants to eat Jerry, but has to avoid becoming a catch for Tom.