Zack gaat voor het eerst naar zijn nieuwe school. Hij leert Milo kennen en leert dat bij Milo alles als een wervelwind van calamiteiten gaat.

After science teacher Mrs. Murawski announces a science project, Milo, Zack, and Melissa must overcome Murphy's Law to protect an egg and their grades.

Milo is allowed to attend his first school football game since the home team, The Geckos will lose anyway, but discovers a way he can help them win.

While on the subway on a school field trip, Milo’s car gets thrown off course and he, Zack and Melissa discover an underground city of subterranean creatures.

Sara wants to go see The Doctor Zone Files movie with Milo, but worries about potential problems.

Milo and the gang spend the entire day chasing after his doctor’s note that excuses an entire semester of absences, illness and shenanigans caused by Murphy’s Law.

The other school kids, led by Melissa and Zack, throw a surprise birthday party for Milo at a go-kart arena.

Zack, Melissa, and Milo attend an opera performance with Amanda, but Milo accidentally ends up backstage and attempts to prevent any havoc from occurring.

It's career day and Milo is having a hard time deciding what his career should be. He tries to decide while visiting the water works, fire department, and hospital. But of course, everything goes wrong. Meanwhile, Dakota and Cavendish try and make sure a truck full of pistachios makes it to the pistachio warehouse.

Milo and his friends visit a dude ranch. While horse back riding, they meet a girl named Jackie who joins their posse, and Zack is smitten with love. But, Jackie leads them into more danger than usual. Meanwhile, Sara is going crazy because the ranch reminds her of scenes from The Doctor Zone Files, and invites other fans to join in the geek fest.

When Milo accidentally joins another family on their vacation, the new family must learn to cope with Murphy’s Law.

Milo and Zack try to help Melissa overcome her secret fear of roller coasters.

Milo and Melissa share their most embarrassing stories, but Zack refuses to reveal his past.

The gang participates in a school event that combines both the academic and athletic decathlon.

A jaded science substitute teacher, Ms. Baxter, re-discovers her love of teaching after a life-altering day with Milo.

Cavendish and Dakota compete against two of the agency’s top operatives, Brick and Savannah, to impress their boss.

At a donation drive, Milo accidentally gives away his mother's vintage T-shirts. Meanwhile, Cavendish and Dakota are assigned to protect the pistachios at the zoo.

Amanda is concerned that Milo will ruin everything at her carefully orchestrated school dance.

Milo, Melissa, Zack, and Mort's band enters the battle of the bands, where Zack discovers his old boy band is competing.

When Melissa’s dad drives her and Milo into town on a decommissioned old fire engine, chaos ensues.

Milo and Melissa finally tell Zack the story of the infamous Llama Incident.

When Cavendish and Dakota stop Milo from destroying a pistachio plant, they change the future. Pistachio plants become sentient and take over the planet, so Cavendish, Dakota and Milo must race through time to save the future.

Milo wants to get an autograph from his favorite actor, Tobias Toopanen, who is shooting a film in town.

Elliot Decker is hired as the school’s head safety monitor.

Milo, Zack and Melissa set out in search of a missing robot that previously escaped.

Milo begins to sleepwalk through some nearby woods. Meanwhile, Cavendish and Dakota have a "ditch day" from pistachio duties after their ordeal with the Pistachions.

The students take a trip on the school yacht.

Parents become children at Back to School Night.

Elliot gets to see what the world would be like without Milo.

Milo runs a race as Cavendish and Dakota gets stuck in the Old West.

With Milo away skiing, Sara finally feels safe enough to go on a date.

Dakota travels back in time to save Cavendish.

Milo, Cavendish, and Dakota travel back to 1965 and inspire the creation of Dr. Zone only to encounter a sinister plot to take over the world.

Zack doesn’t think anything about Halloween can scare him anymore, but he didn’t account for Murphy’s Law.

Milo surprises his parents by inviting the extended Murphy family to town for Christmas, multiplying the effects of Murphy’s Law.