Sezono nuolatiniai aktoriai 6

1. 

   Sonequa Martin-Green

   Michael Burnham

2. 

   Doug Jones

   Saru

3. 

   Mary Wiseman

   Sylvia Tilly

4. 

   Anthony Rapp

   Paul Stamets

5. 

   Jason Isaacs

   Gabriel Lorca

6. 

   Shazad Latif

   Ash Tyler

Kviestinė kino žvaigždė 15

1. 

   Wilson Cruz

   Dr. Hugh Culber

2. 

   Javid Iqbal

   Voq

3. 

   Michelle Yeoh

   Captain Philippa Georgiou

4. 

   Dennis Andres

   Engineer Rance

5. 

   Jordana Blake

   Betarian Girl

6. 

   Christopher Russell

   Milton Richter

7. 

   Kenneth Mitchell

   Kol

8. 

   Sara Mitich

   Airiam

9. 

   Tasia Valenza

   Shenzhou Computer (voice)

10. 

    Mary Chieffo

    L'Rell

11. 

    Jayne Brook

    Admiral Katrina Cornwell

12. 

    Rekha Sharma

    Commander Landry

13. 

    Julianne Grossman

    Discovery Computer (voice)

14. 

    Oyin Oladejo

    Lt. Cmdr. Joann Owosekun

15. 

    Emily Coutts

    Lt. Cmdr. Keyla Detmer

Filmavimo grupė 11