The Philippine version of 1 vs. 100 was first aired on ABS-CBN on August 25, 2007. It is hosted by veteran Filipino quiz host Edu Manzano, from Pilipinas, Game KNB?, and Weakest Link. A single player goes up against 100 other contestants. The One gains money for each mob member eliminated, but if the One answers incorrectly at any point of the game, the game ends and he or she leaves with nothing. The grand prize of the show is ₱2,000,000.

The program is the fourth franchise the network acquired from its creator Endemol and it is also the most expensive, due to the studio's sheer size to accommodate the Mob.

The first season ended on April 19, 2008. Its run was supposed to have ended a long time ago, as the program revealed, but it was extended twice due to popular demand.