Riggs and Murtaugh look into the murder of one of L.A.'s fashion expeditors and discover an underground DEA operation. With Trish and the kids away, Murtaugh goes on a 'bender'. Riggs has all-too-real dreams of Miranda.

Riggs and Murtaugh are forced to work with DEA agent Karen Palmer—again— to protect Leo Getz, an ambulance-chasing attorney who was linked to the Cartel. As the three delve further into the case, they begin to realize that Leo may not be the only one with a target on his back. Riggs begins to view Agent Palmer in a new light. Murtaugh is left worried after Trish makes a spontaneous decision.

Riggs and Murtaugh team up again with Palmer, and together they gain inside knowledge of dangerous new cartel operations. As Riggs’ attachment to Palmer deepens, so do his impulsive actions, further worrying Avery and Delgado. Trish explores the potential of an amazing new career opportunity.

A doctor is found dead in the pool of a wellness clinic. Riggs suspects a drug angle and asks Agent Palmer for help.

Murtaugh and Riggs investigate the mysterious death of famous singer Shaye's bodyguard. Murtaugh turns to his daughter—a fan of the singer—to learn more about Shaye's background and uncover the possible suspects. Riggs learns the responsibilities that come with being in a relationship with help from Murtaugh.