Astrid, la figlia di Bull, viene rapita. La T.A.C. deve fare appello a tutta la sua esperienza per trovarla. Bull sospetta che il rapitore sia qualcuno collegato al suo passato.

La difesa della TAC nei confronti di un cliente, processato per aver divulgato segreti governativi, è resa difficile dalle reazioni emotive di Bull; il quale, evidentemente, non ha ancora superato il trauma del rapimento di sua figlia.

Bull, che soffre ancora di attacchi d'ansia dal rapimento di sua figlia, accetta di difendere il figlio di un imprenditore, accusato di aver ucciso la sua ragazza del liceo 22 anni prima.

Bull si gioca tutte le risorse della TAC in una Class Action contro una ditta produttrice di pericolose sigarette elettroniche che hanno causato il ferimento di 146 persone e la morte di una.

Per evitare che i suoi problemi con la Giustizia non siano d'intralcio, il team della TAC chiede a Bull di non prendere parte alla difesa di un uomo d'affari portato in causa da due delle sue tre figlie.

Mentre Olivia cerca di capire se riuscirà a difenderlo contro l'accusa di corruzione, Bull, per distrarsi, accetta il caso di un'ostetrica accusata di frode professionale ed esercizio abusivo della professione medica.

I problemi legali di Bull passano dal professionale al personale quando nuove prove coinvolgono sua moglie, Izzy, nel suo processo per corruzione.

A Bull e Chunk serve un miracolo di Natale per evitare 15 anni di prigione ad una giovane assistente di un'agenzia sportiva, accusata di aver fornito una dose letale di droga ad una famosa atleta.

Bull aiuta una donna a citare in giudizio gli sviluppatori di un programma per computer che ha erroneamente identificato suo figlio come un criminale, portandolo ad essere ucciso dalla Polizia.

Bull and Chunk aim to prove that their client, a woman on trial for murder, committed the crime due to a lack of behavioral control caused by a brain tumor; Taylor is suspected by the FBI of committing cybercrimes.

The TAC team finds itself in a tense and unprecedented situation when Bull faces off against Marissa and her new boss in court, following her departure from the company. Also, Taylor's professional life works against her during her custody battle with her ex-husband.

The TAC team gets a rare glimpse into Bull’s personal life when his estranged brother of 13 years, Jacob Bull, unexpectedly arrives in New York. Also, TAC represents a financial investor accused by the FBI of running a Ponzi scheme with his father to defraud their clients of millions of dollars.

Bull helps his friend, Army psychiatrist Colonel Victor Taggert, mount a diminished capacity defense for a sergeant accused of killing a fellow soldier. Also, Marissa forges a romantic connection with her art dealer, Henri Fray, a French gallery owner in need of legal assistance to stop an auction house from selling a piece of art that should be repatriated.

Bull helps an agoraphobic client bring a wrongful death suit against the alleged killer of his beloved aunt, but the client’s inability to testify in person threatens the trial. Also, Taylor forges a connection with TAC’s agoraphobic client, and Chunk’s new relationship hits a snag when his mother, Adaline, visits.

Bull takes a frustratingly passive role in court during a medical malpractice suit, when he helps the surgeon who saved his life after his heart attack and must defer to her browbeating attorney on trial strategy. Also, Taylor fights the urge to check into the background of Henri Fray, Marissa’s new love interest.

Bull and Izzy experience marital discord when Bull has TAC lead the defense for Diana Lindsay, his ex-girlfriend who’s accused of killing her lover’s wife. Also, personal conflicts abound for the TAC team when Chunk finds himself defending Diana in court against his boyfriend and prosecutor, Robert.

Izzy hires Bull and TAC to defend a jockey accused of committing arson against a stable owner who fired him.

Bull puts aside his personal grievances to help AUSA Reilly, who prosecuted him for jury tampering, bring one of the world’s most dangerous drug lords to justice. As the pair enter into a hesitant partnership, Bull’s unconventional style clashes with the lawyer’s commitment to working by the book.

When Bull is sidelined with a back injury, Marissa and Chunk are forced to go to court without him to defend Marissa’s closest childhood friend, Kyla, a tech CEO accused of wrongfully terminating an employee. Also, Danny contemplates what she wants out of life following a near-death experience.

Bull breaks from the stress he's been under for months when a mysterious delivery causes him to blackout for hours, leaving him with no memory of his movements.

Bull and the team head to court one last time to finalize a negligent homicide defense that will change the nature of their company and their lives forever.