After a surprise attack, Lorenzo and Giuliano search for the culprits. The trail leads the brothers to the Pazzis, but treachery lies closer at hand.

Lorenzo's power play comes at a cost and stirs up outrage. With leadership comes sacrifice as he travels to Rome and weighs an advantageous match.

The death of the pope brings strategic challenges as Lorenzo negotiates with the Duke of Milan and welcomes his new bride, Clarice, to Florence.

Lorenzo aims to strengthen ties with the Pazzis and proposes a treaty with Venice. Clarice appeals to Lucrezia and learns the way to Lorenzo's heart.

In opposition to the pope, Lorenzo moves quickly to acquire the strategic city of Imola. A forbidden love flowers between Giuliano and Simonetta.

The papal army advances as important coalitions shift. Meanwhile, Lorenzo negotiates a crucial treaty, and Jacopo attempts a major power grab.

As forces threaten a fragile alliance, the Pazzis embark on a murderous plan to destroy the Medicis while Lorenzo seeks to make peace with Rome.