曾是最强最年少的阴阳师、以驱散所有污秽为目标的少年焰魔堂辘轳，自经历“雏月的悲剧”污秽屠杀事件之后，决心放弃阴阳师的身份来度过漫无目标的人生。阴阳师少女化野红绪来到星火寮驱除污秽，恰巧遇到辘轳，两人卷入超巨大污秽的战斗中。红绪命悬一线，面对曾经的梦魔，辘轳终于站了出来。

辘轳的麒麟臂帮红绪解除了危机，本以为就此再无瓜葛的两人在阴阳师宿舍相遇，以最强为目标的红绪看不起毫无干劲的辘轳，两人间水火不容。星火寮再次出现污秽，红绪请求参战，在同伴面前大显身手。号称阴阳师之首的阴阳之神，土御门有马登场，这个变态裤衩男竟然要红绪与辘轳结婚生子，这是什么情况？

　　真所谓冤家路窄，刚返校的辘轳就在班上遇到了转学而来的未婚妻红绪。红绪的高颜值一出场就秒杀了所有男生，而她正巧坐在辘轳的青梅竹马，音海萤良后面。前辈们和污秽拼尽全力战斗，察觉事态棘手的红绪果断翘课援助。独自一人郁郁寡欢的辘轳被萤良拉到了游乐园，是时候来一波青梅竹马的存在感了。

　　周日，阴阳师同伴全都出门办事，家里就剩下辘轳和红绪了。辘轳被前辈亮悟一顿说教，一气之下在街上随便溜达，晚上才回到家。然而他一到家，却听到了亮悟被困祸野的消息，慌了神的辘轳向未婚妻求助，于是两人立马组队去营救亮悟。亮悟命悬一线之际，夫妻档终于帅气出场了。

　　现在污秽已经被各地的阴阳师们压制住了，只有明神町的污秽出现率远高于其他地区，土御门派出得力干将前去调查。队长亮悟重伤住院，此时污秽作祟，红绪暂时担任小队长，带着辘轳等人前去驱除污秽。没想到目的地竟是一所小学，现场出现了一个神秘少年，他就是土御门派来的十二天降中的朱雀。

　　红绪总是早退，成了班上的迷之转校生，更有传言说她和不良少年混在一起。作为班长的萤良坐不住了，不停找红绪搭讪，誓要拯救红绪。亮悟出院，星火寮小队全员到齐，辘轳也回归队伍，红绪暂时闲了下来。茧良对红绪穷追不舍，还用点心收买女主的胃，这一对又能否牵手成功呢？

　　“爱的丘比特”有马大人再次登场，他将辘轳和红绪带到所谓的试炼之所，其实就是一座超豪华别墅，让他俩孕育神子。看着超大游泳池和情侣大床房，辘轳和红绪彻底懵了，两人来到各自的卧室，还没缓过神的时候，就被关在了奇怪的房间里。密室闯关练默契，效果真是立竿见影啊。

　　茧良不希望辘轳再当阴阳师，为了辘轳的将来，茧良与红绪起了争执。听到辘轳的回答后茧良愤然离去，却落入了魔爪，黑历史即将大白于天下。又一位十二天降，天若清弦登场，一出手就秒杀了污秽，没想到他竟然是茧良的父亲和辘轳的师父。两年前轰动阴阳连的真相被说出，红绪和辘轳瞬间反目成仇。

　　辘轳承认是他杀死了雏月的伙伴们，包括红绪的双胞胎哥哥石镜悠斗，就在红绪准备复仇时，悠斗却突然出现了。原来悠斗才是引发“雏月的悲剧” 的元凶，为了获得污秽的力量，他用污秽坠落之法将同伴全部化为污秽。曾今的至亲好友如今不共戴天，得知真相的红绪能否重新振作起来？

　辘轳和红绪的同居生活被打断，十二天降之一的“天后”御币岛昴突然来访，她曾是红绪的师傅。一心想着提升战斗力的辘轳请求天后指导他们修行，天后欣然答应，辘轳和红绪拿着天后给他们的纸条就出发了。两人来到服装店换上新衣服，天后所谓的修行原来就是公费约会啊。

　　昴对辘轳和红绪的夫妻特训还没有结束，打算让昴指导自己战斗的辘轳和红绪完全没有如愿以偿，但昴认为两人心意相通是他们现在首先要掌握的。为了能够得到指导，辘轳和红绪接受了昴的捉迷藏测试，在测试中他们揣测昴的思维模式，并开始关注彼此的想法，这种默契在实战中很快得到了应用。

　　辘轳和红绪相处融洽，电灯泡昴也终于走了，就在辘轳结束了一天的练习准备好好休息时，红绪的暗黑料理也做好了，味道简直让人上天。为了纠正红绪的独特口味，辘轳决定亲自下厨。红绪外出夜跑却迟迟未归，原来红绪遇到了污秽，就在她与敌人战斗时，未知的少年神威出现，而他的目标正是双星阴阳师。

　　辘轳和红绪遇到了婆裟罗神威，神威有着人的姿态却并非人类，而他正是杀害红绪双亲的凶手，红绪被神威打得遍体鳞伤，但她仍要执意报仇。在辘轳的说服下，受伤的红绪放弃这次的复仇，辘轳代替她出战。辘轳的力量让神威兴奋不已，神威竟然拿出咒符，用阴阳师的装备对付辘轳。

It's Tanabata at the Seika Dorm, and everyone is reminiscing while they think about what their wishes for the future will be.

Ryogo gets introduced to an attractive young exorcist by Fushihara, an exorcist from the neighboring area, causing him to question whether or not exorcists should pursue romantic relationships in face of the otherworldly threats that menace their lives.

After harsh words from Seigen, the Twin Stars are frustrated with how powerless they feel. Mayura decides to help cheer her exorcist friends up, in spite of a warning from her father...

Seigen attacks Yuuto, which proves useless. Yuuto fatally wounds Seigen who casts a barrier around the Twin Star Exorcists and the fainted Mayura. Seigen resolves to blow himself up; however, Rokuro and Benio escape from inside the barrier, which again Yuuto congratulates. Seigen is saved minus one arm and Rokuro manages to land a punch on Yuuto who is shocked. He then announces that he will wait for Rokuro's answer (whether he will join Yuuto on the dark side) at a place where there are precious memories for the both of them: Hiinatsuki Dormitory. Seigen and Mayura were hospitalized: Seigen undergoing surgery and Mayura still unconscious. Jissama has received information that the Twelve Guardians has been mobilized to destroy Yuuto and he gives Rokuro a package that Seigen had been wanting to give him. Inside, there is the black exorcist uniform that Seigen wore. Rokuro wears the uniform and announces to Benio that he will defeat Yuuto even with the Twelve Guardians mobilized.

Rokuro has sworn to defeat Yuto. But... how? The Twin Star Exorcists look at the facts and try to find a way to strengthen their odds against an opponent that outclasses them in nearly every way.

It's all been leading up to this. With their new Resonance abilities, the Twin Star Exorcists take the fight directly to Ijika Yuto. Will it be enough to defeat the twisted, evil exorcist?

Yuto has been dominating the Twin Star Exorcists so far, but can help from an unexpected source change the course of their battle? (Note: This episode is the point where the anime fully diverges from the manga)

Two years have passed since their battle with Yuto, and the Twin Star Exorcists have gotten better with age. But when they find something unexpected in Magano, there's no telling what it could mean for their future.

The hellish world of Magano, home of the Kegare, has begun to leak into our reality. Can the Twin Star Exorcists stop the growing influence before it spells doom for the town of Narukami?

The Twin Stars head out of town to seal a Dragon Spot, and Benio is confronted with the infamy caused by her brother.

The Twin Stars' tour across Japan to seal the Kegare-spawning Dragon Spots makes a detour to an amusement park, and Sae makes a new friend that Benio and Rokuro aren't happy about.

The Twin Stars head down to Nagoya and encounter a baseball stadium that has been taken over by a Basara.

The Twin Star Exorcists meet a pair of twin Basara brothers, whose teamwork might be a match for our heroes' powers... And the mastermind behind the Dragon Spots finally reveals himself.

While the Twin Stars tour Japan, Mayura tries to step up her skills as an exorcist.

A Dragon Spot in Kumano results in a brief detour before the Twin Stars and Sae arrive in Kyoto, and they meet the strongest member of the Twelve Guardians.

The head of the Exorcist Union is attacked by the Basara responsible for the the Dragon Spots. And the Twin Star Exorcists finally learn just where Sae came from.

With the secret behind the Dragon Spots and Sae's origin revealed, the path to salvation is clear. But are the Twin Stars willing to part ways with the girl who's become like a daughter to them? And if they're not, can they help the Twelve Guardians resist the flood of Kegare coming through the Dragon Spot?

Kinako wakes up alone in the Seika Dorm after the trip to Kyoto. As he searches for Benio, he reminisces about how they first met.

The Twin Stars reflect on their past, and Rokuro begins to question his own origins.

Kuranashi prepares the next phase of his plan, and sends the Basara who have allied with him to take on the Twelve Guardians.

Two of the Twelve Guardians, Zeze Miku and Sada Sakura, take on the ravenous Basara named Moro.

A Basara is targetting the Twin Star Exorcists, and the only one standing in his way is Shimon. But will the winged guardian save Rokuro and Benio, or be their ultimate downfall?

Chijiwa has wrapped Shimon, along with the rest of the school, in his marionette strings to force them to attack the Twin Stars. Can Rokuro, Benio, and Mayura find a way to free their friends, or will they be forced to fight?

It's the quiet before the storm as the Twin Stars and their friends have a moment of rest before Kuranashi unleashes his plot.

Kuranashi unveils his deadly game, and if the Twin Star Exorcists don't win, it could mean the death of everyone in the town of Narukami.

Mayura and Seigen face off against Kuranashi, but the Basara has a wicked trick up his sleeve. Does the daughter-father team stand a chance against the mastermind of the attack on Narukami?

The Twin Star Exorcists fight the giant Kegare ravaging Narukami while it floats in the sky, as the Twelve Guardians try to make sure the floating city can return to the ground safely.

With the Twelve Guardians caught in Kuranashi's trap, it's now up to the Twin Star Exorcists to free them. But what chance do they stand against the newly powerful Basara?

The threat Kuranashi had posed is over, but the Twin Stars don't get to celebrate for long when an old foe returns.

Rokuro is reeling from what he has learned about his past, and Head Exorcist Arima explains the full scope of what Abe no Seimei set in motion, over a thousand years ago.

After learning about his true nature from Arima, and what it could potentially mean for the entire world, Rokuro makes a decision.

Rokuro has decided to fight Yuto alone. Without Benio, and with the other higher ranked exorcists out of commission, does he stand a chance?

As they battle over the fate of the world, Yuto reveals the nature of his obsession with Rokuro.

Rokuro has become the Cataclysm King, and will soon be responsible for cleansing nearly all of humanity from the Earth. Abe no Seimei offers Benio a way to turn him back to normal, but at what cost?

Rokuro attempts to save Benio but even if he succeeds, can the Twin Star Exorcists prevent the creation of Abe no Seimei's new world?

The greatest Exorcist of all time intends to wipe humanity's yin away in order to create a world where there will be no more free will, or individuality. Can the Twin Star Exorcists stop him?