Noel Fitzpatrick and his team treat Staffordshire bull terrier Lulu, who has been hit by a car and had her pelvis smashed into more than 25 pieces. The professor's only option is to pin the larger pieces back together in an operation that will require all his expertise. Noel and his team also treat a giant schnauzer called Florence who has a sore knee and a pointy-eared Jack Russell called Muffin who has a mysterious problem with her back legs.

Basset hound Barney is `top dog' at home, enjoying salmon and venison as some of his favourite treats. But lately Barney's vertebrae have been causing him problems and Noel Fitzpatrick needs to perform high-risk surgery using 3D-printed implants. The professor also treats a giant mastiff called Tank, who is suffering from severe arthritis and needs radical surgery on both elbows, and a family puppy who has fractured his foot jumping off a bed. Now he requires specially developed surgical treatment.

Professor Noel Fitzpatrick treats a border collie in a lot of pain with a suspicious lump on its ankle. However, the dog's recovery does not go to plan and proves extremely challenging. A short-haired cat arrives with a sore hip from jumping off the sofa, and it seems a hip replacement may be the best option, and a golden labrador is rushed into Fitzpatrick's sister clinic in Guildford with a lump growing on its side.

A two-year old mastiff with a bone tumour in its leg undergoes pioneering surgery, only to return a few weeks later suffering pain in its foot. A tiny pug faces the prospect of euthanasia after losing control of its hind legs, but neurologist Colin Driver thinks spinal surgery could give hope, and a Rhodesian ridgeback is brought in suffering from lameness. Surgery seems like the only option, but Noel and the owners are concerned whether this is the right course of action in the long run.

Noel treats a Labrador suffering with severe arthritis in its elbow, and suggests using stem cells to help with the inflammation, while one of the team's senior neurologists deals with a Chihuahua born with fluid on the brain. Plus, a man comes all the way from France with his Labrador cross, which requires high-end surgery for elbow dysplasia.

A Great Dane comes to the clinic needing an operation on its spine, but when Noel Fitzpatrick discovers the dog has laryngeal paralysis, the prospect of surgery suddenly becomes much more complicated. There are also two Labradors in for treatment. One needs a knee replacement, while the other has a leg tumour that may require amputation. But there may be bad news.

A two-year-old Bengal cat is rushed in after being hit by a car, and when it turns out to have a broken back and a dislocated spine, Noel Fitzpatrick agrees to do what he can - but he makes no promises. A German shepherd requires a total elbow replacement, a difficult operation using a custom printed implant system, and a Rottweiler puppy is treated for a genetic condition that has destroyed the cartilage on its ankle bone.