Kate discovers that a patient is using Viagra to cheat on his wife; Jack gives a blood transfusion even though it's against the patient's Jehovah's Witness religion; a musician fears his creativity may be stifled by the medicine Aaron prescribes for his bipolar disorder; Joe's son drives the staff crazy as he roams the hospital behaving exactly like his father.

A member of Jack's basketball team sustains a near-fatal injury during a game; Bobby disagrees about the need for his patient to have heart surgery.

During surgery to resolve an HIV-positive woman's post-partum complications, Diane accidentally cuts herself and is exposed to the virus; problems arise between Jack and Lisa when he discovers that she's been seeing Robert; a homeless man takes shelter in the hospital's main entrance; an unidentified man is hit by a train after trying to save a child; Jack takes up golf in the hospital.

Billy ponders euthanasia when Gordy is diagnosed with rheumatoid arthritis; Lisa tries to help a woman with metastatic breast cancer get into an experimental group even though the woman doesn't fit the study parameters; Aaron's patient confesses to murder.