Jesse struggles to escape a past that is slowly catching up to him. A mysterious entity comes to earth, leaving a wave of destruction in its wake.

Jesse tries to be a "good preacher," unaware that a mysterious duo is after him. Meanwhile, the enigmatic Cowboy is introduced.

Jesse makes Quincannon a bet he can't refuse; and Cassidy works to fend off the angels. Meanwhile, Tulip tries to bring justice to Annville.

After his stunt with Quincannon, Jesse is Annville's newest rock star; and Tulip and Cassidy connect. Meanwhile, the Cowboy makes a tragic decision.

Jesse finally comes face to face with Deblanc and Fiore and learns about the mysterious entity that has taken over his body.

Jesse is on the run while those around him face life-altering decisions. The Cowboy returns to Ratwater to exact his revenge.