Miss Piggy is woedend op Kermit omdat hij Elizabeth Banks heeft uitgenodigd voor haar talkshow 'Up Late with Miss Piggy'. Fozzie Beer ontmoet de ouders van zijn vriendin en de met een Grammy onderscheiden rockband Imagine Dragons laat zijn nieuwe single horen.

In een poging Miss Piggy blij te maken koppelt Kermit haar aan Josh Groban, die haar allerlei ideeën aandraagt voor het verbeteren van 'Up Late with Miss Piggy'. Fozzie wordt uitgenodigd voor een feest bij Jay Leno thuis. Iedereen ergert zich aan Bobo omdat hij koekjes van de padvinderij van zijn dochter verkoopt.

Fozzie drijft iets te ver door als Kermit hem raad geeft, waarop Nick Offerman te hulp schiet. Christina Applegate is te gast bij 'Up Late' en heeft een verrassing voor Miss Piggy, die niet in goede aarde valt. Pepe, Rizzo en Liam Hemsworth proberen Gonzo te helpen met online daten.

Miss Piggy and Reese Witherspoon have a heated rivalry but when the two volunteer for Habitat for Humanity, their feud escalates to a whole new level. Meanwhile, Fozzie and his girlfriend hit a rough patch.

Kermit is scrambling to find the perfect birthday gift for Denise, so he turns to Miss Piggy for help. Meanwhile, Kristin Chenoweth agrees to do a gig with The Electric Mayhem and inadvertently causes a rift between the band.

Kermit is feeling the pressure at work and is forced to go to a private Yoga retreat where he runs into a stressed out Jason Bateman. Meanwhile, with Kermit out of the office, Scooter is left to run the show and things go from bad to worse.

Scooter books his long time TV crush, Chelsea Handler, who really heats things up both on 'Up Late' and in Scooter's personal life. Meanwhile, Fozzie wants to take it to the next level with Becky but when Kermit and Denise go on a double date with them, Kermit discovers that Becky might have a few skeletons in her closet.

After a show-stopping duet with Miss Piggy on “Up Late with Miss Piggy,” Joseph Gordon-Levitt joins Scooter, Pepe, and the gang for poker night. The Great Gonzo gears up to perform his dream stunt and Dave Grohl challenges Animal to a drum-off.

The gang is preparing for the annual “Up Late” live Christmas special with, special guest Mindy Kaling. Animal is in charge of tinsel, Sweetums hangs the lights, Sam Eagle strategically places the mistletoe – everything is in order. Or so it seems. Meanwhile, Miss Piggy offers relationship advice to Fozzie, which forces her to reevaluate her relationship with Kermit. Yolanda rigs the Secret Santa gift exchange, and Echosmith performs at the crew’s Christmas party.

The whole crew just returned from hiatus, and everyone is rested, recharged and ready to get back to work. But when a new branding guru comes in to revamp "Up Late," the gang rallies together and realizes that they don't need gimmicks and hijinks; they just need each other and a couple of familiar tunes to get them back on track.

When Miss Piggy suffers a scandalous wardrobe malfunction, the network is outraged, and Piggy is forced to question everything she stands for, but Kermit and the gang rally together and come to her defense. Meanwhile, Gonzo misses his ex-girlfriend Camilla, so Pepe and Rizzo decide to throw a house party to cheer him up.

Miss Piggy goes to an aerial silks class in at attempt to make new friends and Gonzo, Pepe and Rizzo fall under Pache’s spell.

Sparks fly when Kermit and Miss Piggy pretend that they are back together for the sake of Kermit’s impressionable nephew Robin. And now that Camilla is taking up all of Gonzo’s time, Pepe and Rizzo audition for a replacement wingman.

When Miss Piggy breaks her leg rehearsing a dance number, Kermit gathers the crew and they broadcast “Up Late” from the hospital. Back at the studio, Rizzo, Pepe and Yolanda find creative ways to keep Pache occupied so he doesn’t ruin the show while Kermit is out.

After her stint in the hospital, Miss Piggy and Kermit reevaluate their relationship, and Kermit turns to Jack White (The White Stripes) for advice.