Pravidelné obsadenie série 10

1. 

   Melissa Benoist

   Kara Danvers / Supergirl / Kara Zor-El

2. 

   Chyler Leigh

   Alex Danvers / Sentinel

3. 

   David Harewood

   J'onn J'onzz / Martian Manhunter

4. 

   Katie McGrath

   Lena Luthor

5. 

   Jesse Rath

   Querl 'Brainy' Dox / Brainiac-5

6. 

   Nicole Maines

   Nia Nal / Dreamer

7. 

   Azie Tesfai

   Kelly Olsen / Guardian

8. 

   Julie Gonzalo

   Andrea Rojas / Acrata

9. 

   Staz Nair

   William Dey

10. 

    Peta Sergeant

    Nyxlygsptlnz / 'Nyxly'

Hosťujúce hviezdy 8

1. Tricia Collins

   Reporter #2

2. 

   Sandy Robson

   Scar

3. Nina Ann Solberg

   Reporter #1

4. 

   Sharon Leal

   M'gann M'orzz

5. 

   Claude Knowlton

   Silas

6. 

   Jason Behr

   Zor-El

7. 

   Jon Cryer

   Lex Luthor

8. Simon Webb

   Philippe

Štáb 6