Elenco Principal da Temporada 8

1. 

   멜리사 베노이스트

   Kara Danvers / Supergirl / Kara Zor-El

2. 

   Chyler Leigh

   Alex Danvers / Sentinel

3. 

   David Harewood

   J'onn J'onzz / Martian Manhunter

4. 

   케이티 맥그라스

   Lena Luthor

5. 

   Jesse Rath

   Querl 'Brainy' Dox / Brainiac-5

6. 

   Nicole Maines

   Nia Nal / Dreamer

7. 

   Sam Witwer

   Ben Lockwood / Agent Liberty

8. 

   Mehcad Brooks

   James 'Jimmy' Olsen / Guardian

Convidados Especiais 10

1. 

   Azie Tesfai

   Kelly Olsen / Guardian

2. 

   David Ajala

   Manchester Black

3. 

   William MacDonald

   Dr. Kaplan

4. Byron Brisco

   Guard #2

5. 

   Christina Lewall

   Trauma Doctor

6. 

   Lincoln McGowan

   Guard

7. 

   Amos Stern

   Guard #3

8. 

   Andrea Brooks

   Eve Tessmacher

9. 

   Jon Cryer

   Lex Luthor

10. 

    Robert Baker

    Otis Graves

Equipa Técnica 5