An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Rival gangs bring their war to Med. Halstead and Charles work with a brain cancer patient who's refusing treatment. Tensions run high in the OR when a patient's transplanted uterus fails.

Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.

As Jack Dayton prepares to launch OR 2.0's IPO, Marcel and Grace search for data that may put a wrench in his plans. Charles helps a schizophrenic patient who is anxious about prom. Asher clashes with Abrams when his wife becomes her patient.