When a subway train goes off the tracks, Marcel volunteers to help the victims. Taylor and Halstead must decide if they’re willing to risk their jobs to save a patient. Asher and Archer clash over a pregnant patient.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer’s son is in danger. Marcel and Charles help a kidney transplant patient experiencing psychosis. Asher and Halstead grow closer.

Halstead relies on Marcel and Med's newly donated OR 2.0 to save his patient. Charles helps an elderly, confused patient who's mourning the loss of his high school sweetheart. As their wedding day approaches, Choi and April run into some roadblocks.