In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Supply chain disruptions dramatically impact Med, causing Marcel to clash with other doctors. Maggie reveals something to Ben. Choi and Archer help a patient with ALS.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer’s son is in danger. Marcel and Charles help a kidney transplant patient experiencing psychosis. Asher and Halstead grow closer.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.

Goodwin and Charles clash as negotiations drag on between the administration and the custodial workers' union. Asher fights to keep a mother and her newborn baby together.

The hospital is in disarray when the janitors go on strike. Marcel treats a young girl injured on her family's farm. Charles and Cuevas' schizophrenic patient returns to Med.

Halstead and Cuevas struggle to diagnose a patient with a rare disorder. CFD and Med staff work to free a paranoid father trapped in the MRI suite. Tanaka-Reed gets an ego check.

As Jack Dayton prepares to launch OR 2.0's IPO, Marcel and Grace search for data that may put a wrench in his plans. Charles helps a schizophrenic patient who is anxious about prom. Asher clashes with Abrams when his wife becomes her patient.