The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Dr. Choi treats a teen mother who abandoned her newborn baby in an alley, as the staffers must make difficult decisions about the teen's future. Also, a hypochondriac with chest pains is treated, as is a patient suffering from possible dementia.

Dark family secrets emerge when Dr. Rhodes' father is honored for making a large donation to the hospital. Meanwhile, the Department of Homeland Security arrives when two injured airplane stowaways are brought to the hospital and Dr. Sarah Reese must deliver heartbreaking news to a boy.

A husband makes a request following his wife's death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives at the hospital after swallowing magnets; Sarah has last-minute thoughts about her residency.

A teen patient with abdominal pain firmly refuses any drugs. Meanwhile, Dr. Halstead reconnects with his past when treating a patient; a pregnant woman does everything in her power not to deliver the child; and Dr. Rhodes tries to avoid family issues.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment, but doesn't want it from them.

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the E.D.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.