Dr. Manning and Dr. Halstead become skeptical of a patient's injuries when the victim of a car accident is brought into the hospital. Ethan and April have a difficult time understanding Emily's attachment to her boyfriend despite recent developments. Will and Natalie brace for their joint bachelor/bachelorette party.

Halstead takes heat for making an unauthorized move to treat his pregnant patient. Choi becomes personally invested when treating a homeless veteran. Rhodes and Bekker deal with a patient who desperately needs a liver transplant.

Halstead treats a woman on the verge of freezing to death. Dr. Charles' ex-wife receives some concerning news. Choi handles a lymphoma patient with viral meningitis and a complicated family. Manning makes a house call.

Caroline has news to share, forcing Dr. Charles to make a serious decision about their relationship. Maggie meets her sister's new boyfriend, but discovers danger may lie ahead. Dr. Rhodes experiences a devastating loss while Dr. Choi and April are faced with an unexpected challenge that strengthens their relationship.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.

Dylan and Will deal with a dishonest patient whose lupus is in remission. A wealthy donor makes inappropriate advances toward Stevie. Vanessa, Crockett and Charles try to convince a young woman to have life-saving surgery.

Dylan's loyalty to Med and the police department is challenged when an old family friend and veteran cop exhibits concerning behavior. The annual random drug testing puts a doctor’s career in jeopardy. Ethan tries a risky old-school method on a patient. Will helps Stevie search for her mother.

Archer and Asher clash over a patient with close ties to Goodwin. After a patient is shot during a home invasion, Scott and Marcel help with the investigation. Maggie and Halstead work to protect a patient who is in the country illegally.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Goodwin and Charles clash as negotiations drag on between the administration and the custodial workers' union. Asher fights to keep a mother and her newborn baby together.

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.

As Jack Dayton prepares to launch OR 2.0's IPO, Marcel and Grace search for data that may put a wrench in his plans. Charles helps a schizophrenic patient who is anxious about prom. Asher clashes with Abrams when his wife becomes her patient.

Frustrated with an insurance company, Ahmad takes matters into her own hands, jeopardizing Med's negotiations and Marcel's first day on the board. Charles helps a woman's depressed husband. Asher's first date takes a surprising turn.