The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

A husband makes a request following his wife's death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives at the hospital after swallowing magnets; Sarah has last-minute thoughts about her residency.

Dr. Rhodes treats his mentor and Goodman faces personal issues in the Season 1 finale. Also: April deals with a disorderly patient; Dr. Manning's past catches up with her; and Sarah's graduation day arrives, but she remains conflicted about her future.

Dr. Rhodes begins a fellowship in cardiothoracic surgery, only to have problems with his new boss. Dr. Choi is the new chief resident. Dr. Charles approaches Sarah with an interesting opportunity that catches her off-guard. April faces her recently discovered illness.

Dr. Manning tends to a young cancer patient and struggles to inform the parents of her dire condition. Elsewhere, Dr. Reese gets contacted by Danny, the troubled young man, and turns to Dr. Charles and Det. Lindsay for help in resolving a difficult situation. Goodwin and Maggie do their best to clear the logjam in the hospital and Dr. Rhodes fine-tunes his instincts after both Dr. Latham and Dr. Halstead pick up on things he doesn't. Meanwhile, a teenage science geek and her friends impress Dr. Choi and Natalie with their bio-engineering lab.

It's a long night on the graveyard shift at Chicago Med, especially for Dr. Reese, who must deal with pronouncing patients dead on more than one occasion. April gets called in to work, much to the dismay of Tate, who pressures her to slow down. Meanwhile, Dr. Charles passes along some vital news to Dr. Latham, and Goodwin asks Dr. Rhodes to work on a most unusual patient.

Chicago Med braces for an influx of trauma patients when a pre-dawn pileup finds the hospital in full scramble mode. As a result of the storm and emergencies, supplies become limited and Goodwin, Dr. Manning and Dr. Halstead must deal with making an impossible decision. Meanwhile, Dr. Choi handles a severely burned patient who has one final request and Dr. Charles deals with an agitated patient.

A new hotshot doctor arrives at Chicago Med causing competition for Dr. Rhodes, Dr. Halstead and Dr. Manning work together to diagnose a Syrian refugee without a medical record. When Robin is admitted back into the hospital for more complications, Dr. Reese takes a different approach to her treatment. Distracted from work because of Robin's worsening case, Dr. Charles is challenged by Goodwin and Noah hosts a graduation party that brings everyone together.

The doctors of Chicago Med take their opinions to the extreme as they try to bring justice to the perpetrator in the shooting of Dr. Charles. Dr. Halstead and Dr. Manning work on a heart-wrenching case that forces them to examine their own matters of the heart. Though Robin’s brain tumor was removed and she is discharged from the rehabilitation center, Dr. Rhodes remains on edge that her problems are not quite resolved. Meanwhile, Rhodes gets blindsided by his colleague Dr. Bekkar, Maggie sticks up for a patient and Dr. Choi and April try to navigate their new working relationship.

Dr. Rhodes second guesses removing himself from the team working to separate conjoined twins; Dr. Choi and April make a startling discovery about his sister; Dr. Charles uncovers troubling information concerning Dr. Reese's father.

Bekker takes drastic action to keep Rhodes from leaving Med for good. Meanwhile, Halstead questions Manning's feelings about their upcoming wedding, Ethan receives shocking news about his sister, and Dr. Charles mourns a loss.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

April finds herself in a dangerous situation and Natalie gets an update on Will. Dr. Rhodes gears up for a gala honoring his hybrid O.R. and tries to convince Dr. Bekker to join him.

Connor, who is in hot water with the hospital's Oversight Committee, handles a gunshot victim with unexpected ties to Halstead. Maggie feels guilty about the return of a former patient. Charles has an awkward first date.

Dr. Charles and Caroline set some major plans. Ava fights to keep her relationship with Connor. Agent Lee informs Will of news that may put his life in danger.

Will and Natalie battle for their lives after a car accident. An investigation is launched following the suspicious death of Cornelius Rhodes. Maggie receives life-changing news. Dr. Charles cuts his honeymoon short to tend to a patient.

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie’s memory from the accident starts to return.

The staff adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

The outcome of Will's investigation weighs heavily on his mind as he works with Dylan to save a 4-month-old patient. Stevie and Vanessa both struggle to keep their secrets. Crockett and Blake work with Abrams to save a patient in need of a liver transplant.

Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Halstead treat a patient who's been in an iron lung for 60 years.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Halstead relies on Marcel and Med's newly donated OR 2.0 to save his patient. Charles helps an elderly, confused patient who's mourning the loss of his high school sweetheart. As their wedding day approaches, Choi and April run into some roadblocks.

Shocking information threatens Jack Dayton's surgery and the future of OR 2.0. Archer goes rogue to save a patient in need. Maggie questions her future at Med.

When the E.D. is flooded with patients from a crash, the entire team is pulled in to help. Charles can't shake the feeling that he knows the new E.D. attending. Archer has second thoughts on the eve of his kidney transplant.